Results 1 to 10 of about 10,021 (178)
Molecular Evolution of Phosphoprotein Phosphatases in Drosophila [PDF]
PLoS ONE, 2011 Phosphoprotein phosphatases (PPP), these ancient and important regulatory enzymes are present in all eukaryotic organisms. Based on the genome sequences of 12 Drosophila species we traced the evolution of the PPP catalytic subunits and noted a ...
Viktor Dombrádi +2 more
exaly +6 more sources
Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro [PDF]
STAR Protocols, 2023 Summary: Serine/threonine protein phosphatase 2 (PP2A) forms heterotrimeric holoenzymes, where a scaffold subunit bridges the PP2A catalytic subunit to a B regulatory subunit, e.g., B55α.
Jason S. Wasserman +6 more
doaj +2 more sources
The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. [PDF]
PLoS ONE, 2020 Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan ...
Rebecca S Rivard +2 more
doaj +2 more sources
Substrate and phosphorylation site selection by phosphoprotein phosphatases [PDF]
Trends in Biochemical Sciences, 2023 Arminja Kettenbach
exaly +2 more sources
A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans [PDF]
Molecular and Cellular Proteomics, 2018 Isha Nasa, Scott P Lyons
exaly +2 more sources
BBA Advances, 2021 Background: Phosphoprotein phosphatases (PPP) belong to the PPP Sequence family, which in turn belongs to the broader metallophosphoesterase (MPE) superfamily.
David Kerk +5 more
doaj +1 more source
Life, 2021 Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj +1 more source
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana
Frontiers in Cellular and Infection Microbiology, 2021 Protein phosphorylation and dephosphorylation are increasingly recognized as important processes for regulating multiple physiological mechanisms.
Alma Reyna Escalona-Montaño +10 more
doaj +1 more source
Biomolecules, 2023 Sodium bicarbonate stress caused by NaHCO3 is one of the most severe abiotic stresses affecting agricultural production worldwide. However, little attention has been given to the molecular mechanisms underlying plant responses to sodium bicarbonate ...
Qiang Li +7 more
doaj +1 more source
Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification
Molecular Systems Biology, 2023 Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because methods to investigate this at scale are lacking.
Jamin B Hein +10 more
doaj +1 more source