Results 1 to 10 of about 10,403 (145)

Molecular Evolution of Phosphoprotein Phosphatases in Drosophila [PDF]

PLoS ONE, 2011
Phosphoprotein phosphatases (PPP), these ancient and important regulatory enzymes are present in all eukaryotic organisms. Based on the genome sequences of 12 Drosophila species we traced the evolution of the PPP catalytic subunits and noted a ...
Viktor Dombrádi, László Kovacs, Zsolt Karányi   +2 more
exaly   +6 more sources

Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro [PDF]

STAR Protocols, 2023
Summary: Serine/threonine protein phosphatase 2 (PP2A) forms heterotrimeric holoenzymes, where a scaffold subunit bridges the PP2A catalytic subunit to a B regulatory subunit, e.g., B55α.
Jason S. Wasserman, Felicity Feiser, Seren Palacio, Kishan Patel, Joy Gonzalez, Holly Fowle, Xavier Graña   +6 more
doaj   +2 more sources

The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. [PDF]

PLoS ONE, 2020
Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan ...
Rebecca S Rivard, Julia M Morris, Matthew J Youngman   +2 more
doaj   +2 more sources

Holding the PP2A and PP4 protein phosphatases at bay: emerging roles of FBXO42 and CCDC6 [PDF]

EMBO Reports
The Ser/Thr phosphoprotein phosphatases (PPPs, PP1-PP7) are major regulators of phospho-dependent signaling and precise regulation of their activity is essential for cellular homeostasis (Nilsson, 2019).
Jakob Nilsson
doaj   +2 more sources

A functional map of phosphoprotein phosphatase regulation identifies an evolutionarily conserved reductase for the catalytic metal ions [PDF]

Nature Communications
Serine/threonine phosphoprotein phosphatases (PPPs) are conserved metalloenzymes and key regulators of intracellular signaling. Here, we systematically map the components and residues required for PP2A-like phosphatase (PP2A/PP4/PP6) function using ...
Bob Meeusen, Sara M. Ambjørn, Jiri Veis, Rachel C. Riley, Gianmatteo Vit, Brooke L. Brauer, Mads H. Møller, Elora C. Greiner, Camilla B. Chan, Anna M. Schmoker, Blanca Lopez Mendez, Melanie B. Weisser, Dimitriya H. Garvanska, Hao Zhu, Norman E. Davey, Arminja N. Kettenbach, Egon Ogris, Jakob Nilsson   +17 more
doaj   +2 more sources

Substrate and phosphorylation site selection by phosphoprotein phosphatases [PDF]

Trends in Biochemical Sciences, 2023
Arminja Kettenbach
exaly   +2 more sources

A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans [PDF]

Molecular and Cellular Proteomics, 2018
Isha Nasa, Scott P Lyons
exaly   +2 more sources

The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases [PDF]

British Journal of Pharmacology, 2012
Jp Spiers
exaly   +2 more sources

Origin of the Phosphoprotein Phosphatase (PPP) sequence family in Bacteria: Critical ancestral sequence changes, radiation patterns and substrate binding features

BBA Advances, 2021
Background: Phosphoprotein phosphatases (PPP) belong to the PPP Sequence family, which in turn belongs to the broader metallophosphoesterase (MPE) superfamily.
David Kerk, Mario E. Valdés-Tresanco, Ryan Toth, Sergei Yu. Noskov, Kenneth K.-S. Ng, Greg B. Moorhead   +5 more
doaj   +1 more source

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases

Life, 2021
Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj   +1 more source