Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation
Scientific Reports, 2021 The family of Phosphoprotein Phosphatases (PPPs) is responsible for most cellular serine and threonine dephosphorylation. PPPs achieve substrate specificity and selectivity by forming multimeric holoenzymes. PPP holoenzyme assembly is tightly controlled,
Scott P. Lyons +4 more
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Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase [PDF]
, 2003 The cofactor-dependent phosphoglycerate mutase (dPGM) superfamily contains, besides mutases, a variety of phosphatases, both broadly and narrowly substrate-specific.
Rigden, Daniel J., Daniel J. Rigden
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Frontiers in Cell and Developmental Biology, 2023 PP2A-serine/threonine protein phosphatases function as heterotrimeric holoenzymes, composed of a common scaffold (A-subunit encoded by PPP2R1A/PPP2R1B), a common catalytic (C-subunit encoded by PPP2CA/PPP2CB), and one of many variable regulatory (B ...
E. Alan Salter +3 more
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Phosphoprotein Phosphatase Activity in the Thyroid
Experimental Biology and Medicine, 1975 Phosphoprotein phosphatase activity in the calf thyroid was found in various subcellular fractions. The relative amount in each fraction varied according to the substrate used: The 500g fraction had the highest specific activity when protamine was used, while the 5000g fraction was highest when histone was used. Triton X-100 tended to increase activity
S W, Spaulding, G N, Burrow
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Kinases and Phosphatases: The Challenge of a New Journal Entirely Focused on Post-Translational Modifications [PDF]
, 2022 On behalf of all the Editorial Board members and the MDPI staff, I’m pleased to announce the publishing of the inaugural issue of the Kinases and Phosphatases journal [...
Salvi, Mauro, Mauro Salvi
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Cytokine-stimulated Phosphoflow of PBMC Using CyTOF Mass Cytometry
Bio-Protocol, 2015 Phosphorylation of tyrosine, serine, and threonine residues is critical for the control of protein activity involved in various cellular events. An assortment of kinases and phosphatases regulate intracellular protein phosphorylation in many different ...
Rosemary Fernandez, Holden Maecker
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Charged with meaning: the structure and mechanism of phosphoprotein phosphatases [PDF]
, 1995 The new structural data obtained for PP1 and calcineurin—A resolve many of the outstanding questions about the catalytic nature of the Ser/Thr phosphatases. These enzymes may now be firmly classed as two-metal ion phosphatases.
Widlanski, Theodore S. +1 more
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Journal of Lipid Research, 1978 We previously showed that preincubation of a 10,000 g supernatant (S(10)) from rat liver for 20 min at 37 degrees C dramatically increased the subsequent incorporation of [(14)C]acetate into sterols.
C D Goodwin, S Margolis
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Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells. [PDF]
PLoS ONE, 2012 Receptor desensitization is a ubiquitous regulatory mechanism that defines the activatable pool of receptors, and thus, the ability of cells to respond to environmental stimuli. In recent years, the molecular mechanisms controlling the desensitization of
Michelle B Henesy +7 more
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The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]
, 2007 Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid +26 more
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