Hyperphosphatemia, Phosphoprotein Phosphatases, and Microparticle Release in Vascular Endothelial Cells. [PDF]
J Am Soc Nephrol, 2015 Hyperphosphatemia in patients with advanced CKD is thought to be an important contributor to cardiovascular risk, in part because of endothelial cell (EC) dysfunction induced by inorganic phosphate (Pi).
Abbasian N +8 more
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Nature Communications, 2020 The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their ...
Bernhard Hoermann +11 more
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Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases
BioTechniques, 2007 Synthetic peptides incorporating various chemical moieties, for example, phosphate groups, are convenient tools for investigating protein modification enzymes, such as protein phosphatases (PPs). However, short peptides are sometimes poor substrates, and
Samvel Kochinyan +5 more
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Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
Frontiers in Cell and Developmental Biology, 2018 Dynamic changes in protein phosphorylation govern the transitions between different phases of the cell division cycle. A “tug of war” between highly conserved protein kinases and the family of phosphoprotein phosphatases (PPP) establishes the ...
Isha Nasa +3 more
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Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase. [PDF]
BMC Plant Biol, 2016 Background: SNF1-related protein kinases 2 (SnRK2s) are key regulators of the plant response to osmotic stress. They are transiently activated in response to drought and salinity. Based on phylogenetic analysis SnRK2s are divided into three groups.
Krzywińska E +9 more
europepmc +2 more sources
Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana
Frontiers in Cellular and Infection Microbiology, 2021 Protein phosphorylation and dephosphorylation are increasingly recognized as important processes for regulating multiple physiological mechanisms.
Alma Reyna Escalona-Montaño +10 more
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Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification
Molecular Systems Biology, 2023 Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because methods to investigate this at scale are lacking.
Jamin B Hein +10 more
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Biomolecules, 2023 Sodium bicarbonate stress caused by NaHCO3 is one of the most severe abiotic stresses affecting agricultural production worldwide. However, little attention has been given to the molecular mechanisms underlying plant responses to sodium bicarbonate ...
Qiang Li +7 more
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Sequence homology between purple acid phosphatases and phosphoprotein phosphatases Are phosphoprotein phosphatases metalloproteins containing oxide-bridged dinuclear metal centers? [PDF]
, 1990 The amino acid sequences of mammalian purple acid phosphatases and phosphoprotein phosphatases are shown to possess regions of significant homology. The conserved residues contain a high percentage of possible metal-binding residues.
Averill, Bruce A. +3 more
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Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases
Toxins, 2023 Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, and terrestrial ecosystems.
Galina Nugumanova +4 more
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