Results 11 to 20 of about 10,021 (178)

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Nature Communications, 2020
The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their ...
Bernhard Hoermann, Thomas Kokot, Dominic Helm, Stephanie Heinzlmeir, Jeremy E. Chojnacki, Thomas Schubert, Christina Ludwig, Anna Berteotti, Nils Kurzawa, Bernhard Kuster, Mikhail M. Savitski, Maja Köhn   +11 more
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Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

Toxins, 2023
Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, and terrestrial ecosystems.
Galina Nugumanova, Eugene D. Ponomarev, Sholpan Askarova, Elizaveta Fasler-Kan, Natasha S. Barteneva   +4 more
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Isotopically Dimethyl Labeling-Based Quantitative Proteomic Analysis of Phosphoproteomes of Soybean Cultivars

Biomolecules, 2021
Isotopically dimethyl labeling was applied in a quantitative post-translational modification (PTM) proteomic study of phosphoproteomic changes in the drought responses of two contrasting soybean cultivars.
Atieh Moradi, Shuaijian Dai, Emily Oi Ying Wong, Guang Zhu, Fengchao Yu, Hon-Ming Lam, Zhiyong Wang, Al Burlingame, Chengtao Lin, Alireza Afsharifar, Weichuan Yu, Tingliang Wang, Ning Li   +12 more
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Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

eLife, 2017
The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity.
Joshua J Filter, Byron C Williams, Masumi Eto, David Shalloway, Michael L Goldberg   +4 more
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The Scaffold Immunophilin FKBP51 Is a Phosphoprotein That Undergoes Dynamic Mitochondrial-Nuclear Shuttling

Cells, 2022
The immunophilin FKBP51 forms heterocomplexes with molecular chaperones, protein-kinases, protein-phosphatases, autophagy-related factors, and transcription factors.
Nadia R. Zgajnar, Cristina Daneri-Becerra, Ana Cauerhff, Mario D. Galigniana   +3 more
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Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis

Frontiers in Cell and Developmental Biology, 2018
Dynamic changes in protein phosphorylation govern the transitions between different phases of the cell division cycle. A “tug of war” between highly conserved protein kinases and the family of phosphoprotein phosphatases (PPP) establishes the ...
Isha Nasa, Isha Nasa, Arminja N. Kettenbach, Arminja N. Kettenbach   +3 more
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Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Cells, 2021
Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation ...
Syevda Tagirova Sirenko, Ihor Zahanich, Yue Li, Yevgeniya O. Lukyanenko, Alexey E. Lyashkov, Bruce D. Ziman, Kirill V. Tarasov, Antoine Younes, Daniel R. Riordon, Yelena S. Tarasova, Dongmei Yang, Tatiana M. Vinogradova, Victor A. Maltsev, Edward G. Lakatta   +13 more
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Development of a novel pharmacophore model to screen specific inhibitors for the serine-threonine protein phosphatase calcineurin

Biochemistry and Biophysics Reports, 2022
Calcineurin (CaN) is a calcium/calmodulin-dependent serine/threonine phosphatase with a crucial role in cellular homeostasis. It is also the target of the Food and Drug Administration (FDA) approved immunosuppressant drugs FK506 and cyclosporine A ...
Abhisek Mukherjee, Karina Cuanalo-Contreras, Abha Sood, Claudio Soto   +3 more
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Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases

BioTechniques, 2007
Synthetic peptides incorporating various chemical moieties, for example, phosphate groups, are convenient tools for investigating protein modification enzymes, such as protein phosphatases (PPs). However, short peptides are sometimes poor substrates, and
Samvel Kochinyan, Luo Sun, Inca Ghosh, Tanya Barshevsky, Jie Xu, Ming-Qun Xu   +5 more
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The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells

Toxins, 2011
Cyclin D1 is a key regulator of the cell cycle that is over expressed in more than half of breast cancer patients. The levels of cyclin D1 are controlled primarily through post-translational mechanisms and phosphorylation of cyclin D1 at T286 induces its
David L. Brautigan, Jessica R. Edelson
doaj   +1 more source