Results 11 to 20 of about 9,926 (149)
The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. [PDF]
PLoS ONE, 2020 Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan ...
Rebecca S Rivard +2 more
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Substrate and phosphorylation site selection by phosphoprotein phosphatases. [PDF]
Trends Biochem Sci, 2023 Nguyen H, Kettenbach AN.
europepmc +2 more sources
Sequence homology between purple acid phosphatases and phosphoprotein phosphatases [PDF]
FEBS Letters, 1990 The amino acid sequences of mammalian purple acid phosphatases and phosphoprotein phosphatases are shown to possess regions of significant homology. The conserved residues contain a high percentage of possible metal‐binding residues. The phosphoprotein phosphatases 1, 2A and 2B are proposed to be iron‐zinc metalloenzymes with active sites isostructural
Vincent, John B., Averill, Bruce A.
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A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans. [PDF]
Mol Cell Proteomics, 2018 Lyons SP +8 more
europepmc +2 more sources
Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)
eLife, 2017 The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity.
Joshua J Filter +4 more
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Cells, 2022 The immunophilin FKBP51 forms heterocomplexes with molecular chaperones, protein-kinases, protein-phosphatases, autophagy-related factors, and transcription factors.
Nadia R. Zgajnar +3 more
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Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
Frontiers in Cell and Developmental Biology, 2018 Dynamic changes in protein phosphorylation govern the transitions between different phases of the cell division cycle. A “tug of war” between highly conserved protein kinases and the family of phosphoprotein phosphatases (PPP) establishes the ...
Isha Nasa +3 more
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Cells, 2021 Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation ...
Syevda Tagirova Sirenko +13 more
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Biochemistry and Biophysics Reports, 2022 Calcineurin (CaN) is a calcium/calmodulin-dependent serine/threonine phosphatase with a crucial role in cellular homeostasis. It is also the target of the Food and Drug Administration (FDA) approved immunosuppressant drugs FK506 and cyclosporine A ...
Abhisek Mukherjee +3 more
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Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases
BioTechniques, 2007 Synthetic peptides incorporating various chemical moieties, for example, phosphate groups, are convenient tools for investigating protein modification enzymes, such as protein phosphatases (PPs). However, short peptides are sometimes poor substrates, and
Samvel Kochinyan +5 more
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