Results 21 to 30 of about 40,005 (218)

Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)

eLife, 2017
The small phosphoprotein pCPI-17 inhibits myosin light-chain phosphatase (MLCP). Current models postulate that during muscle relaxation, phosphatases other than MLCP dephosphorylate and inactivate pCPI-17 to restore MLCP activity.
Joshua J Filter, Byron C Williams, Masumi Eto, David Shalloway, Michael L Goldberg   +4 more
doaj   +1 more source

Isotopically Dimethyl Labeling-Based Quantitative Proteomic Analysis of Phosphoproteomes of Soybean Cultivars

Biomolecules, 2021
Isotopically dimethyl labeling was applied in a quantitative post-translational modification (PTM) proteomic study of phosphoproteomic changes in the drought responses of two contrasting soybean cultivars.
Atieh Moradi, Shuaijian Dai, Emily Oi Ying Wong, Guang Zhu, Fengchao Yu, Hon-Ming Lam, Zhiyong Wang, Al Burlingame, Chengtao Lin, Alireza Afsharifar, Weichuan Yu, Tingliang Wang, Ning Li   +12 more
doaj   +1 more source

The Scaffold Immunophilin FKBP51 Is a Phosphoprotein That Undergoes Dynamic Mitochondrial-Nuclear Shuttling

Cells, 2022
The immunophilin FKBP51 forms heterocomplexes with molecular chaperones, protein-kinases, protein-phosphatases, autophagy-related factors, and transcription factors.
Nadia R. Zgajnar, Cristina Daneri-Becerra, Ana Cauerhff, Mario D. Galigniana   +3 more
doaj   +1 more source

Diverse physiological functions for dual-specificity MAP kinase phosphatases [PDF]

, 2006
A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals.
Keyse, Stephen M, Dickinson, Robin J
core   +1 more source

Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Cells, 2021
Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation ...
Syevda Tagirova Sirenko, Ihor Zahanich, Yue Li, Yevgeniya O. Lukyanenko, Alexey E. Lyashkov, Bruce D. Ziman, Kirill V. Tarasov, Antoine Younes, Daniel R. Riordon, Yelena S. Tarasova, Dongmei Yang, Tatiana M. Vinogradova, Victor A. Maltsev, Edward G. Lakatta   +13 more
doaj   +1 more source

Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury [PDF]

, 2011
Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion ...
Birk, Philipp, Morote-Garcia, Julio C., Rosenberger, Peter, Peter Rosenberger, Eldh, Therese, Andreas Straub, Klemens König, Philipp Birk, Therese Eldh, König, Klemens, Julio C Morote-Garcia, Straub, Andreas, Köhler, David, David Köhler   +13 more
core   +2 more sources

Development of a novel pharmacophore model to screen specific inhibitors for the serine-threonine protein phosphatase calcineurin

Biochemistry and Biophysics Reports, 2022
Calcineurin (CaN) is a calcium/calmodulin-dependent serine/threonine phosphatase with a crucial role in cellular homeostasis. It is also the target of the Food and Drug Administration (FDA) approved immunosuppressant drugs FK506 and cyclosporine A ...
Abhisek Mukherjee, Karina Cuanalo-Contreras, Abha Sood, Claudio Soto   +3 more
doaj   +1 more source

The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells

Toxins, 2011
Cyclin D1 is a key regulator of the cell cycle that is over expressed in more than half of breast cancer patients. The levels of cyclin D1 are controlled primarily through post-translational mechanisms and phosphorylation of cyclin D1 at T286 induces its
David L. Brautigan, Jessica R. Edelson
doaj   +1 more source

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases? [PDF]

, 2008
Background: Tartrate-resistant acid phosphatases (TRAcPs), also known as purple acid phosphatases (PAPs), are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The human enzyme is a major histochemical marker
David A Hume, Jodie Robinson, Gerhard Schenk, Hadler, K.ieran S., Burrows, Allan, Cassady A Ian, Hadler, K. S., Huber, Thomas, Guddat, L. W., Weber, J., Allan Burrows, Flanagan, J. U., Kelly Gregory, Robinson, J., Schenk Gerhard, Hume David A, Gregory Kelly, Robinson, Jodie, Huber Thomas, Guddat, Luke W., Burrows, A., Hadler, Kieran S., Burrows Allan, A Ian Cassady, Guddat, Luke W, Luke W Guddat, Hume, David A, Hume, D. A., Hume, David A., Kieran S Hadler, Flanagan, Jack U., Weber Jane, Robinson Jodie, Schenk, Gerhard, Kelly, Gregory, Hadler Kieran S, Jack U Flanagan, Jane Weber, Weber, Jane, Cassady, A. Ian, Cassady, A. I., Schenk, G., Guddat Luke W, Flanagan, Jack U, Flanagan Jack U, Huber, T., Hadler, Kieran S, Thomas Huber, Kelly, G., Cassady, Alan Ian   +49 more
core   +1 more source

Phosphatase Protection Assay: 14-3-3 Binding Protects the Phosphate group of RSG from λ Protein Phosphatase

Bio-Protocol, 2015
14-3-3 proteins regulate diverse cellular processes in eukaryotes by binding to phospho-serine or threonine of target proteins. One of the physiological functions of 14-3-3 is to bind and protect phosphate groups of the target proteins against ...
Takeshi Ito, Yohsuke Takahashi
doaj   +1 more source