Results 191 to 200 of about 40,110 (297)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis. [PDF]

BMC Syst Biol, 2018
Buiga P, Elson A, Tabernero L, Schwartz JM.   +3 more
europepmc   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes

, 2016
Pierre Mélard, Yamina Idrissi, Laëtitia Andrique, Sandrine Poglio, Martina Prochazkova‐Carlotti, Sabine Berhouet, Cécile Boucher, Elodie Laharanne, Edith Chevret, Anne Pham‐Ledard, Andréa Carla de Souza Góes, Veronique Guyonnet‐Dupérat, Alice Bibeyran, François Moreau‐Gaudry, B. Vergier, M. Beylot‐Barry, Jean‐Philippe Merlio, David Cappellen   +17 more
openalex   +2 more sources

Crystal structure of the catalytic domain of human VHY, a dual‐specificity protein phosphatase [PDF]

, 2005
Tae‐Sung Yoon, Dae Gwin Jeong, Jae Hoon Kim, Yoon Hea Cho, Jeong Hee Son, Ji‐Won Lee, Seong Eon Ryu, Seung Jun Kim   +7 more
openalex   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

miR-106a Reduces 5-Fluorouracil (5-FU) Sensitivity of Colorectal Cancer by Targeting Dual-Specificity Phosphatases 2 (DUSP2). [PDF]

Med Sci Monit, 2018
Qin Y, Chen X, Liu Z, Tian X, Huo Z.
europepmc   +1 more source

Inhibition of dual-specificity phosphatase 26 by ethyl-3,4-dephostatin: Ethyl-3,4-dephostatin as a multiphosphatase inhibitor

, 2016
Huiyun Seo, Sayeon Cho
openalex   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

SHP-2 Is a Dual-specificity Phosphatase Involved in Stat1 Dephosphorylation at Both Tyrosine and Serine Residues in Nuclei [PDF]

, 2002
Tong Wu, Y. Kate Hong, Xudong Wang, Mike Y. Ling, Ana Maria Dragoi, Alicia S. Chung, Andrew G. Campbell, Zhi-Yong Han, Gen‐Sheng Feng, Y. Eugene Chin   +9 more
openalex   +1 more source