Results 271 to 280 of about 40,110 (297)

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

DSPicable V: TuMV exploits a dual-specificity phosphatase to suppress MAPK signaling and host resistance. [PDF]

Plant Cell
Osborne R.
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment. [PDF]

Expert Opin Ther Targets
Wu J, Tautz L.
europepmc   +1 more source

Dual-specificity phosphatase 3 knockout female mice are resistant to LPS and to polymicrobial induced septic shock in TNF dependent manner.

, 2013
Souad Rahmouni, Singh, Lien Dejager, Maneesh Singh, Mathieu Amand, Lucia Musumeci, Michel Moutschen, Tomas Mustelin, Claude Libert   +8 more
openalex   +1 more source

Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery. [PDF]

Pharm Sci Adv
Du N, Li Y, Lou Q, Zhang G, Li Y, Li Y.
europepmc   +1 more source

Tissue-specific profiling of human protein phosphatases identifies G6PC1 as a liver cancer-selective biomarker. [PDF]

Discov Oncol
Sarhan AR.
europepmc   +1 more source

JNK signaling dominance in hyperthermia. [PDF]

Cell Stress Chaperones
Enomoto A, Fukasawa T.
europepmc   +1 more source

Interaction between dual specificity phosphatases and JNK scaffolds

, 2005
Emma A. Willoughby
openalex   +1 more source