Results 41 to 50 of about 6,006,276 (250)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Effects of dual tasks and dual-task training on postural stability: a systematic review and meta-analysis [PDF]

, 2017
Shashank Ghai,1,2 Ishan Ghai,3 Alfred O Effenberg1 1Institute of Sports Science, Leibniz University, Hannover, Germany; 2Department of Sports Science, University of Waikato, Hamilton, New Zealand; 3School of Engineering & Life Sciences, Jacobs ...
Ishan Ghai, Ghai S, Ghai, Shashank, Ghai, Ishan, Alfred O Effenberg, Ghai I, Effenberg, Alfred O., Effenberg AO, Shashank Ghai   +8 more
core   +1 more source

Effects of transcranial direct current stimulation on dual-task performance in older and young adults: A systematic review and meta-analysis

Archives of Gerontology and Geriatrics Plus
Background: The ability to successfully perform various physical and cognitive tasks simultaneously is a required goal for older adults (OA). Brain areas such as the dorsolateral prefrontal cortex (DLPFC) are involved in cognitive processing during ...
Jibrin Sammani USMAN, Thomson Wai-Lung WONG, Shamay Sheung Mei NG   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Differential Relationships Between Brain Structure and Dual Task Walking in Young and Older Adults

Frontiers in Aging Neuroscience, 2022
Almost 25% of all older adults experience difficulty walking. Mobility difficulties for older adults are more pronounced when they perform a simultaneous cognitive task while walking (i.e., dual task walking).
Kathleen E. Hupfeld, Justin M. Geraghty, Heather R. McGregor, C. J. Hass, Ofer Pasternak, Rachael D. Seidler, Rachael D. Seidler   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The Effect of Vibrotactile Feedback on Healthy People and People with Vestibular Disorders during Dual-task Conditions [PDF]

, 2013
Vibrotactile feedback (VTF) has been shown to improve balance performance in healthy people and people with vestibular disorders in a single-task experimental condition. However, typical balance activities occur in a multi-task environment.
Lin, Chia-Cheng
core  

Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial

Frontiers in Aging Neuroscience, 2022
BackgroundDeclined cognitive function interferes with dual-task walking ability and may result in falls in older adults with mild cognitive impairment (MCI). The mind-body exercise, Tai Chi (TC), improves cognition and dual-task ability.
Chien-Liang Liu, Chien-Liang Liu, Chien-Liang Liu, Fang-Yu Cheng, Min-Ju Wei, Ying-Yi Liao, Ying-Yi Liao   +6 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source