Results 91 to 100 of about 19,547 (317)

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Coordinated Control of Energy Storage in Networked Microgrids under Unpredicted Load Demands

, 2018
In this paper a nonlinear control design for power balancing in networked microgrids using energy storage devices is presented. Each microgrid is considered to be interfaced to the distribution feeder though a solid-state transformer (SST).
Chakrabortty, Aranya, Cisneros, Rafael, Husain, Iqbal, Khan, Md Tanvir Arafat   +3 more
core   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

An Active Power Decoupling Method for Single Phase DC/AC DAB Converters

IEEE Access, 2019
The existence of the double grid frequency (100 Hz) ripple current in dc/ac dual active bridge (DAB) power converters can degrade their performance and as such these ripples need to be compensated.
Jiang You, D. Mahinda Vilathgamuwa, Negareh Ghasemi, Wynand Louis Malan   +3 more
doaj   +1 more source

Solid-State Transformers for Interfacing Solar Panels to the Power Grid: An Optimum Design Methodology of a High Frequency Transformer for dc-dc Converter Applications [PDF]

, 2016
Nowadays the use of power electronic interfaces to integrate distributed generation with the power grid is becoming relevant due to the increased penetration of renewable energy sources like solar, and the continued ...
George, Kenny
core   +2 more sources

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

T-Type-Based Dual-Active-Bridge DC-DC Converter With Voltage Balancing Capability for Bipolar DC Distribution System

IEEE Access
A dual-active-bridge (DAB) converter has been widely used to construct the dc bus voltage of a dc distribution system. However, in the case of a bipolar dc system, conventional DAB converters fail to regulate the bipolar dc bus voltage levels due to the ...
Jun Young Lee, Jun-Suk Lee, Jee-Hoon Jung   +2 more
doaj   +1 more source

Switching frequency optimization for a Solid State Transformer with Energy Storage Capabilities [PDF]

, 2016
Energy Conversion Congress and Exposition (ECCE), 2016 IEEE (2016.
García Fernández, Pablo, García García, Jorge, Navarro Rodríguez, Ángel, Saeed Hazkial Gerges, Sarah, Schneider, Hannes   +4 more
core   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source