Results 71 to 80 of about 12,700 (294)

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Evaluation of isolated DC/DC converter topologies for future HVDC aerospace microgrids [PDF]

, 2017
High performance power conversion equipment is currently gaining an increasing interest for aircraft applications. In particular, isolated bidirectional DC/DC converters are often proposed for modern HVDC aircraft distribution systems. For such reason an
Costabeber, Alessando, Galea, Michael, Linglin, Chen, Tarisciotti, Luca, Walker, Adam   +4 more
core   +2 more sources

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Innovative heat sink design for enhanced cooling efficiency in Dual Active Bridge (DAB) topology

Journal of Physics: Conference Series
Abstract After in-depth research and analysis, aiming at the heat generation mechanism and limitations of the current heat dissipation method, this paper proposes an innovative heat dissipation design scheme. By optimizing the structural design of the heat sink, the heat dissipation surface area is increased, thus achieving more ...
Chenghong Liu, Zhuowei Xu, Donghao Han, Jian Ma   +3 more
openaire   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Impedance modeling and stability analysis of dual active bridge converter with LC input filter

CES Transactions on Electrical Machines and Systems, 2018
The dual active bridge (DAB) converter is gaining more and more attention in various applications such as energy storage systems, electric vehicles and smart grids.
Fan Feng, Xin Zhang, Fanfan Lin, Hoay Beng Gooi   +3 more
doaj   +1 more source

DC-Link Voltage Coordinated-Proportional Control for Cascaded Converter with Zero Steady-State Error and Reduced System Type [PDF]

, 2016
copyright 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale
Chen, Zhe, Deng, Fujin, Hu, Yanting, Loh, Poh C., Tian, Yanjun   +4 more
core   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement

Advanced Science, EarlyView.
This review synthesizes emerging insights into WUSCHEL (WUS) as a central regulator of plant stem cell fate beyond Arabidopsis, highlighting its roles in regeneration, somatic embryogenesis (SE), and stress adaptation across crops. It explores how WUS‐centered regulatory networks, genome editing, and AI‐guided strategies can be leveraged for precise ...
Zishan Ahmad, Muthusamy Ramakrishnan, Rajeev K. Varshney, Anwar Shahzad, Shamsur Rehman, Bijaya Pant, Qiang Wei   +6 more
wiley   +1 more source

A Three-Level Dual-Active-Bridge Converter With Blocking Capacitors for Bidirectional Electric Vehicle Charger

IEEE Access, 2019
In order to solve the considerable issues of air pollution, climate warming and fossil energy shortage, many governments around the world have formulated policies to encourage the development of electric vehicles over the past decade. This paper proposes
Yang Xuan, Xu Yang, Wenjie Chen, Tao Liu, Xiang Hao   +4 more
doaj   +1 more source