Results 141 to 150 of about 37,917 (298)

Antiplatelet therapy following transcatheter aortic valve implantation

, 2015
There is limited evidence to support decision making on antiplatelet therapy following transcatheter aortic valve implantation (TAVI). Our aim was to assess the efficacy and safety of aspirin-only (ASA) versus dual antiplatelet therapy (DAPT) following ...
Rubino, Paolo, Kikkert, Wouter J, Eltchaninoff, Hélène, Barbanti, Marco, Ussia, Gian Paolo, Poliacikova, Petra, Sharma, Sumeet, Wiegerinck, Esther M. A, Blanchard, Didier, Piek, Jan J, Hassell, Mariëlla E. C. J., Wiegerinck, Esther M. A., Hassell, Mariëlla E. C. J, Durand, Eric, Piek, Jan J., Delewi, Ronak, Baan, Jan, Tamburino, Corrado, STABILE, EUGENIO, Hildick-Smith, David, Hildick Smith, David, Kikkert, Wouter J.   +21 more
core   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Dynamics of hemostasis system parameters in assessing the risk of complications in the patients with acute myocardial infarction receiving antiplatelet therapy

Трансплантология (Москва)
Background. Current treatment of patients with myocardial infarction is based on the strategy of early invasive coronary intervention in combination with dual antiplatelet therapy - with acetylsalicylic acid and a P2Y12 blocker of platelet adenosine ...
T. R. Gvindzhiliya, I. M. Kuzmina, E. V. Klychnikova, E. V. Tazina, A. A. Kochetova, N. A. Muradyan, A. S. Bogdanova   +6 more
doaj   +1 more source

Evaluating the duration of dual antiplatelet therapy in ACS patients post-PCI: A literature review

, 2019
Background: Acute coronary syndrome (ACS) patients who undergo percutaneous coronary intervention (PCI) with stents require downstream dual antiplatelet therapy (DAPT) to reduce the rates of stent thrombosis and ischemic events.(1) According to multiple ...
Bucko, Justine
core  

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

The burden of diabetic foot ulcers in a multi‐ethnic Asian cohort

Diabetic Medicine, EarlyView.
Abstract Aims Diabetic foot ulcers (DFUs) are a major source of morbidity among individuals with diabetes mellitus (DM), imposing a substantial burden on healthcare systems. Our institution established a multidisciplinary service aiming to facilitate early specialist intervention for DFU management.
Zongwen Wee, Yong Mong Bee, Sueziani Binte Zainudin   +2 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel

Vascular Health and Risk Management, 2009
Zuzana Motovska, Petr WidimskyThird Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech RepublicAbstract: Dual oral antiplatelet therapy, aspirin plus thienopyridine, has permitted a rapid increase in the use ...
Zuzana Motovska, Petr Widimsky
doaj  

Small Bowel Lesions and Bleeding Risk in Hemodialysis Patients: A Narrative Review

Hemodialysis International, EarlyView.
ABSTRACT Background Gastrointestinal bleeding is very common among hemodialysis patients. This high bleeding risk is caused by uremic platelet dysfunction, vascular fragility, intradialytic hemodynamic instability, and widespread antithrombotic therapy.
Andreas Smyrlis, Konstantia Kantartzi, Konstantinos Mimidis, Stylianos Panagoutsos   +3 more
wiley   +1 more source