Results 61 to 70 of about 37,917 (298)

Benefits and Risks of Extended Duration Dual Antiplatelet Therapy After PCI in Patients With and Without Acute Myocardial Infarction

, 2015
BACKGROUND The benefits and risks of prolonged dual antiplatelet therapy may be different for patients with acute myocardial infarction (MI) compared with more stable presentations.
Iancu, Adrian C, Windecker, Stephan, Kereiakes, Dean J, Gershlick, Anthony H., Yeh, Robert W, Mauri, Laura, Massaro, Joseph M, Steg, Philippe Gabriel, Gershlick, Anthony H, Cohen, David J., Massaro, Joseph M., Cohen, David J, Cutlip, Donald E, Wiviott, Stephen D., Iancu, Adrian C., Cutlip, Donald E., Rinaldi, Michael J, Tanguay, Jean-Francois, Jacobs, Alice, Wiviott, Stephen D, Kereiakes, Dean J., Yeh, Robert W., Rinaldi, Michael J.   +22 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

Effectiveness of mono antiplatelet therapy vs dual antiplatelet therapy in ischemic stroke or transient ischemic attack—Special subgroup consideration for the African-American Population

, 2020
Purpose: The purpose of this study is to assess the effectiveness of mono antiplatelet therapy vs dual antiplatelet therapy in reducing recurrent stroke and mortality in patients with ischemic stroke or transient ischemic attack (TIA).
Borghol, Amne, Neuliep, Alison, Bergeron, Bree, Brakta, Fatima, Onor, Ifeanyi, Andonie, Gabriela, Castro, Mikee, Hawawini, Fadi, Beyl, Robbie, Zaki, Amir, Zaki, Ahmed, Ahmed, Fahamina   +11 more
core   +1 more source

Emergency Cholecystectomy in Patients Classified as High Risk According to the Tokyo Guidelines 2018: A Real‐World Analysis

Annals of Gastroenterological Surgery, EarlyView.
Emergency cholecystectomy was evaluated in patients with acute cholecystitis classified as non‐recommended for surgery by the Tokyo Guidelines 2018. Major postoperative complications, rather than mortality, better reflected operative risk. Physiological instability, particularly ASA‐PS ≥ 3 and shock status, identified high‐risk patients, suggesting ...
Satoshi Mii, So Yamaki, Daisuke Hashimoto, Kazuki Matsumura, Hiroyuki Ishida, Hidetaka Miyazaki, Yuki Matsui, Yuji Ikeda, Tsukasa Ikeura, Sohei Satoi   +9 more
wiley   +1 more source

Oesophageal submucosal hematoma after flow diverter embolization with favourable outcome treated by discontinuing postoperative antiplatelet therapy for only three days: a case report

JA Clinical Reports, 2019
Background Oesophageal submucosal hematoma is a rare perioperative complication. When this complication develops after endovascular surgery, which requires postoperative antiplatelet therapy, whether to stop antiplatelet therapy or not is controversial ...
Eriko Takeyama, Aiko Wada, Eizo Amano, Hiromi Shibuya   +3 more
doaj   +1 more source

The Case for Routine Genotyping in Dual-Antiplatelet Therapy

Journal of the American College of Cardiology, 2010
Over 1 million coronary stent procedures are performed annually in the U.S., with dual-antiplatelet therapy, which includes the use of both aspirin and clopidogrel, being a cornerstone in the management of these patients after coronary intervention. Now, recent data have surfaced demonstrating altered active metabolite levels of clopidogrel in patients
Damani, Samir B., Topol, Eric J.
openaire   +2 more sources

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. [PDF]

, 2021
BACKGROUND The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation of a drug-eluting coronary stent remains unclear.
Stanković, Goran, Rodriguez, Alfredo E, Roffi, Marco, Ong, Paul J L, Laanmets, Peep, Jüni, Peter, Smits, Pieter C, Donahue, Michael, Colombo, Antonio, Leonardi, Sergio, Vranckx, Pascal, Tonino, Pim A L, Heg, D., Smits, Pieter C., Hildick-Smith, David, Bartunek, Jozef, Windecker, S., Kornowski, Ran, Heg, Dik, MASTER DAPT Investigators, Windecker, Stephan, Alasnag, Mirvat, Morice, Marie-Claude, Ong, Paul J. L., Tonino, Pim A. L., Mahfoud, Felix, Tijssen, Jan, Ozaki, Yukio, Iñiguez, Andrés, Frigoli, Enrico, Rodriguez, Alfredo E., Lesiak, Maciej, Chevalier, Bernard, Moschovitis, Aris, Frigoli, E., Valgimigli, M., Valgimigli, Marco, Onuma, Yoshinobu, Schultz, Carl   +38 more
core   +1 more source

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shojiro Hata, Hirokazu Yamaguchi   +8 more
wiley   +1 more source