Results 1 to 10 of about 8,720 (195)
Cilostazol prevents endothelin-induced smooth muscle constriction and proliferation. [PDF]
PLoS ONE, 2012 Cilostazol is a phosphodiesterase inhibitor that has been shown to inhibit platelet activation. Endothelin is known to be the most potent endogenous growth promoting and vasoactive peptide.
Yoshifumi Kawanabe +6 more
doaj +3 more sources
Cilostazol Suppresses IL-23 Production in Human Dendritic Cells via an AMPK-Dependent Pathway
Cellular Physiology and Biochemistry, 2016 Background/Aims: Cilostazol has been previously demonstrated to inhibit IL-23 production in human synovial macrophages via a RhoA/ROCK-dependent pathway.
Quanxing Shi +9 more
doaj +2 more sources
Comparative Study of Ex Vivo Antiplatelet Activity of Aspirin and Cilostazol in Patients with Diabetes and High Risk of Cardiovascular Disease [PDF]
Endocrinology and Metabolism, 2022 Background The role of aspirin in primary cardiovascular disease prevention in patients with diabetes remains controversial. However, some studies have suggested beneficial effects of cilostazol on cardiovascular disease in patients with diabetes.
Sangmo Hong +2 more
doaj +1 more source
PLoS ONE, 2022 ObjectiveTo evaluate the efficacy and safety of cilostazol, pentoxifylline, beraprost for intermittent claudication due to lower extremity arterial occlusive disease.MethodsRandomized controlled clinical trials were identified from PubMed, Scopus, EMbase,
Xinyu Liang +3 more
doaj +2 more sources
Crystals, 2020 The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano +6 more
doaj +1 more source
PLoS ONE, 2022 PurposeDrug-eluting stents (DESs) play an important role in endovascular therapy (EVT) for femoropopliteal (FP) lesions. Cilostazol improves patency after bare-metal nitinol stent (BNS) implantation for femoropopliteal lesions.
Takashi Miura +10 more
doaj +1 more source
Cardioprotective Effect of Cilostazol on Ischemia-Reperfusion Injury Model
Brazilian Journal of Cardiovascular Surgery, 2021 Introduction: To clarify the potential protective role of cilostazol on rat myocardial cells with ischemia-reperfusion injury (IRI) models. Methods: The study was conducted with three groups of 10 Wistar rats (control group, rats without any coronary ...
Mazlum Sahin +2 more
doaj +1 more source
Cilostazol inhibits accumulation of triglyceride in aorta and platelet aggregation in cholesterol-fed rabbits. [PDF]
PLoS ONE, 2012 Cilostazol is clinically used for the treatment of ischemic symptoms in patients with chronic peripheral arterial obstruction and for the secondary prevention of brain infarction.
Hideki Ito +7 more
doaj +1 more source
Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells. [PDF]
PLoS ONE, 2016 A neuroprotective role of autophagy mediates the degradation of β-amyloid peptide (Aβ) in Alzheimer's disease (AD). The previous study showed cilostazol modulates autophagy by increasing beclin1, Atg5 and LC3-II expressions, and depletes intracellular Aβ
So Youn Park +6 more
doaj +1 more source
Conversion from cilostazol to OPC‐13015 linked to mitigation of cognitive impairment
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Cilostazol may be a novel therapeutic agent for Alzheimer's disease. Its metabolite, OPC‐13015, has a stronger inhibitory effect on type 3 phosphodiesterase than cilostazol.
Satoshi Saito +8 more
doaj +1 more source