Results 31 to 40 of about 8,720 (195)

Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation of AMPK pathway.

PLoS ONE, 2019
Alcoholic liver disease (ALD) is a worldwide health problem and hepatocyte apoptosis has been associated with the development/progression of ALD. However, no definite effective pharmacotherapy for ALD is currently available.
Youn Ju Lee, Mi-Sun Shu, Jong-Yeon Kim, Yun-Hye Kim, Kyeong Hwa Sim, Woo Jung Sung, Jong Ryeol Eun   +6 more
doaj   +1 more source

Protective effects of cilostazol against hemorrhagic stroke: Current and future perspectives

Journal of Pharmacological Sciences, 2016
Cilostazol is a phosphodiesterase-3 inhibitor and is known to have pleiotropic effects including antiplatelet and vasodilatation effects and protective effects on endothelial cells.
Toshinori Takagi, Hideaki Hara
doaj   +1 more source

Cilostazol reduces restenosis after carotid artery stenting [PDF]

, 2009
BackgroundAlthough carotid artery stenting (CAS) has been proposed as an alternative to carotid endarterectomy in cerebral revascularization, restenosis remains an unsolved issue. Cilostazol is a unique antiplatelet drug that has vasodilatory effects and
Akira Matsumura, Tomoji Takigawa, Matsumaru, Yuji, Yuji Matsumaru, Takigawa, Tomoji, Shigeru Nemoto, Hayakawa, Mikito, Mikito Hayakawa, Nemoto, Shigeru, Matsumura, Akira   +9 more
core   +1 more source

Positive chronotropic effects of theophylline and cilostazol in patients with symptomatic sick sinus syndrome who have declined permanent pacing [PDF]

Reviews in Cardiovascular Medicine, 2020
Pacemakers are more commonly recommended than theophylline for sick sinus syndrome (SSS) treatment. The positive effects of cilostazol on bradyarrhythmias also have been reported.
In Tae Jin, Namsik Yoon, Hyung Ki Jeong, Ki Hong Lee, Hyung Wook Park, Jeong Gwan Cho
doaj   +1 more source

The role of cilostazol, a phosphodiesterase 3 inhibitor, on oocyte maturation and subsequent pregnancy in mice. [PDF]

PLoS ONE, 2012
It is important to identify effective contraceptive drugs that cause minimal disruption to physiological processes. Phosphodiesterase 3 (PDE3) inhibitors suppress meiosis in oocytes by decreasing the level of cAMP and blocking the extrusion of the first ...
Min Li, Yang Yu, Jie Yan, Li-Ying Yan, Yue Zhao, Rong Li, Ping Liu, Aaron J Hsueh, Jie Qiao   +8 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Effect of Cilostazol on Myocardial Histomorphological Changes in Ischemia-Reperfusion Injury [PDF]

Introduction: Protecting the myocardium from acute ischemia-reperfusion (IR) injuries during open-heart surgeries is vital for improving outcomes. This study aimed to compare the effects of cilostazol on the nature and extent of histomorphological ...
Artan Jahollari, Anar Amrah, Murat Tavlashoglu, Fazil Abbasov, Mamed Karimov, Mustafa Kurkluoglu, Ziya Shahaliyev   +6 more
core   +2 more sources

Pretreatment with Cilostazol Attenuates Carboplatin Induced Cytotoxicity and Genotoxicity in Bronchial Epithelial Cells (Beas-2B) and Human Blood Lymphocytes [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Cilostazol is a prescription medication for intermittent claudication in patients with peripheral artery disease. Previous research has demonstrated that this 2-oxoquinoline derivative possesses antithrombotic, vasodilator ...
Mohammad Shokrzadeh, Mahboube Rahmati, Elahe Gharehkhani, Rouzbeh Zare, Parsa Pourmohammadi, Shaghayegh Aghajanshakeri   +5 more
doaj  

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model

Scientific Reports
Cilostazol has previously been shown to reduce liver steatosis and enhance hepatic perfusion. We investigated the effects of cilostazol after major hepatectomy in a steatotic rat model. Six weeks prior to surgery, Sprague–Dawley rats were fed with a high-
Sebastian Holländer, Maximilian von Heesen, Gereon Gäbelein, Julie Mercier, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Antonios E. Spiliotis   +7 more
doaj   +1 more source