Results 51 to 60 of about 1,596,902 (278)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Working 9 to 5? Complex patterns of time allocation among managers and professionals in dual career households [PDF]
, 2009 This PhD is a theoretically informed empirical investigation of contemporary patterns of time allocation among managers and professionals in dual career households.
Wheatley, D
core
SA Journal of Industrial Psychology, 2016 Orientation: Spousal support is a crucial area to explore, particularly due to the increased prevalence of dual-career couples in South Africa and the dynamics facing them.
Sumaiyah F. Ahmed, Nasima M.H. Carrim
doaj +1 more source
Physical Education of Students, 2023 Background and Study Aim. The main purpose of the study is to investigate whether the individual responsibility and empathy levels of athlete-students affect the level of social capital. The secondary purpose is to examine the social capital, empathy and
Abdil Arı, Nazlı Deniz Öz
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
This is a concise and practical introduction to the topic of dual career athletes, those sportspeople who balance professional or elite sport with other career or educational pursuits. This book defines the concept of dual careers in sport and explores its significance for athletes, sports organizations, and wider society. It considers why dual careers
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Dual career: balancing success in sport and life
, 2020 A main challenge for many current and aspiring Olympians and Paralympians is to successfully balance education and/or vocational work with their sporting ambitions. This is often referred to as “dual career”.
Howland, L. +3 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source