Results 71 to 80 of about 4,734,173 (343)

Use of both linear and logarithmic transfer functions to increase dynamic range of visual channel [PDF]

open access: yes, 1969
Using both linear and logarithmic transfer functions in the visual channels of a dual channel radiometer increases the dynamic range to better than 1 to 10,000 foot ...
Peretko, H. T.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Research on the Maritime Logistics Pricing Model of Risk-Averse Retailer-Dominated Dual-Channel Supply Chain

open access: yesPolish Maritime Research, 2018
Price decision is studied in a risk-averse retailer-dominated dual-channel supply chain, which consisting of one manufacturers and one retailer with both off-line and on-line channels.
Fang Qing   +3 more
doaj   +1 more source

Impacts of Online and Offline Channel Structures on Two-Period Supply Chains with Strategic Consumers

open access: yesMathematics, 2019
In this paper, the effects of strategic consumer behaviors have been investigated and analyzed with regard to online retailers and offline retailers in a dual-channel supply chain.
Qian Lei, Juan He, Fuling Huang
doaj   +1 more source

Duality of Channel Encoding and Decoding - Part I: Rate-1 Binary Convolutional Codes

open access: yes, 2016
In this paper, we revisit the forward, backward and bidirectional Bahl-Cocke-Jelinek-Raviv (BCJR) soft-input soft-output (SISO) maximum a posteriori probability (MAP) decoding process of rate-1 binary convolutional codes.
Bahl   +7 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Jointly Optimal Channel and Power Assignment for Dual-Hop Multi-channel Multi-user Relaying

open access: yes, 2012
We consider the problem of jointly optimizing channel pairing, channel-user assignment, and power allocation, to maximize the weighted sum-rate, in a single-relay cooperative system with multiple channels and multiple users.
Dong, Min, Hajiaghayi, Mahdi, Liang, Ben
core   +1 more source

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