Results 91 to 100 of about 682,080 (270)

Classical linear vector optimization duality revisited

, 2010
With this note we bring again into attention a vector dual problem neglected by the contributions who have recently announced the successful healing of the trouble encountered by the classical duals to the classical linear vector optimization problem ...
Bot, Radu Ioan, Grad, Sorin-Mihai, Wanka, Gert   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Explanation or Understanding? Movement Studies Between Natural Sciences and Cultural Studies

Physical Culture and Sport: Studies and Research, 2014
Movement studies are - like health studies - placed between natural sciences and cultural studies as well as between quantitative and qualitative methods. That is why they are challenged by some methodological contradictions.
Eichberg Henning
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flat connections and Wigner-Yanase-Dyson metrics

, 2003
On the manifold of positive definite matrices, we investigate the existence of pairs of flat affine connections, dual with respect to a given monotone metric.
Amari, Amari, Amari, Anna Jenčová, Bhatia, Chentsov, Chentsov, Dittmann, Dittmann, Eguchi, Grasselli, Hasegawa, Hasegawa, Hasegawa, Hasegawa, Jenčová, Jenčová, Lesniewski, Nagaoka, Petz, Petz, Petz   +21 more
core   +2 more sources

Synthesis of dual-microring-resonator cross-connect filters

Optics Express, 2005
A new type of resonant, waveguided, 2 x 2 cross-connect optical filter is proposed and synthesized using a microwave filter analog. The optical passbands of the device are determined using 2D scattering matrix theory and the desired response is generated via a synthesis for a combined singly and doubly terminated circuit.
S, Emelett, R, Soref
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Finite-Temperature Fractional D2-Branes and the Deconfinement Transition in 2+1 Dimensions

, 2010
The supergravity dual to N regular and M fractional D2-branes on the cone over \mathbb{CP}^3 has a naked singularity in the infrared. One can resolve this singularity and obtain a regular fractional D2-brane solution dual to a confining 2+1 dimensional N
A Buchel, A Buchel, A Dymarsky, A Loewy, AM Polyakov, B Svetitsky, B Svetitsky, CP Herzog, CP Herzog, CP Herzog, CP Herzog, DJ Gross, DR Morrison, E Witten, Gregory C. Giecold, GT Horowitz, GW Gibbons, I Kanitscheider, IR Klebanov, IR Klebanov, IR Klebanov, IR Klebanov, IR Klebanov, JM Maldacena, KA Intriligator, L Susskind, LJ Romans, M Cvetič, M Cvetič, MA Shifman, N Itzhaki, O Aharony, O Aharony, O Aharony, O Aharony, P Candelas, S Gukov, SA Hartnoll, SS Gubser, SS Gubser, SS Gubser, SS Gubser, VA Novikov   +42 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source