Results 71 to 80 of about 682,080 (270)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Geometric constructions of generalized dual-unitary circuits from biunitarity

SciPost Physics
We present a general framework for constructing solvable lattice models of chaotic many-body quantum dynamics with multiple unitary directions using biunitary connections.
Michael A. Rampp, Suhail A. Rather, Pieter W. Claeys
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Gravitational Instantons and Moduli Spaces of Topological 2-form Gravity

, 1994
A topological version of four-dimensional (Euclidean) Einstein gravity which we propose regards anti-self-dual 2-forms and an anti-self-dual part of the frame connections as fundamental fields.
A. L. Besse, A. Nakamichi, A. S. Schwarz, Akika Nakamichi, C. G. Torre, C. G. Torre, C. G. Torre, D. Anselmi, D. Anselmi, E. Calabi, E. Witten, E. Witten, E. Witten, E. Witten, G. 't Hooft, G. D. Mostov, G. T. Horowitz, G. W. Gibbons, H. Kunitomo, H. Y. Lee, I. Oda, J. F. Plebanski, J. Samuel, K. Kodaira, K. Kodaira, K. Kodaira, M. Abe, M. Blau, M. Blau, M. J. Perry, M. Kontsevich, Mitsuko Abe, P. B. Kronheimer, P. Shanahan, Q Han Park, R. Capovilla, R. Myers, R. Penrose, S. Hawking, S. Kobayashi, S. T. Yau, T. Eguchi, Tatsuya Ueno, V. A. Belinskii   +43 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dual-channel deep graph convolutional neural networks

Frontiers in Artificial Intelligence
The dual-channel graph convolutional neural networks based on hybrid features jointly model the different features of networks, so that the features can learn each other and improve the performance of various subsequent machine learning tasks.
Zhonglin Ye, Zhonglin Ye, Zhonglin Ye, Zhonglin Ye, Zhuoran Li, Zhuoran Li, Zhuoran Li, Zhuoran Li, Gege Li, Gege Li, Gege Li, Gege Li, Haixing Zhao, Haixing Zhao, Haixing Zhao, Haixing Zhao   +15 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On the local representation of synectic connections on Weil bundles

Дифференциальная геометрия многообразий фигур, 2022
Synectic extensions of complete lifts of linear connections in tangent bundles were introduced by A. P. Shirokov in the seventies of the last century [1; 2]. He established that these connections are linear and are real realizations of linear connections
A. Ya. Sultanov, G.A. Sultanova
doaj   +1 more source

Efficient merging of multiple segments of B\'ezier curves [PDF]

, 2015
This paper deals with the merging problem of segments of a composite B\'ezier curve, with the endpoints continuity constraints. We present a novel method which is based on the idea of using constrained dual Bernstein polynomial basis (P.
Gospodarczyk, Przemysław, Lewanowicz, Stanisław, Woźny, Paweł   +2 more
core  

Solutions in Self-Dual Gravity Constructed Via Chiral Equations

, 1994
The chiral model for self-dual gravity given by Husain in the context of the chiral equations approach is discussed. A Lie algebra corresponding to a finite dimensional subgroup of the group of symplectic diffeomorphisms is found, and then use for ...
A. Ashtekar, A. Ashtekar, A. Ashtekar, G. Floratos, H. García-Compeán, J.D. Finley III, J.D.E. Grant, J.F. Plebański, S. Chakravarty, T. Matos, T. Matos, Tonatiuh Matos, V. Husain, V. Husain   +13 more
core   +2 more sources