Results 41 to 50 of about 1,051,029 (290)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Journal of Cheminformatics, 2021 Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A2A receptor (A2AR) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various ...
Leen Kalash +7 more
doaj +1 more source
AI-Enhanced Digital Creativity Design: Content-Style Alignment for Image Stylization
IEEE Access, 2023 This paper presents an AI(Artificial Intelligence)-powered method for enhancing digital creative design through image stylization. To achieve this, we introduce the Content-Style Alignment Module (CSAM), which includes the Dual-Stream Content-Style ...
Lanting Yu, Qiang Zheng
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Dual Descriptor also reveals the Janus-Faced Behaviour of Diiodine [PDF]
, 2020 The diiodine molecule as Janus-faced ligand was evidenced by Rogachev and Hoffmann [A.Y. Rogachev et al., JACS , 2013, 135 , 3262] through an exhaustive investigation based on the Molecular Orbital Theory (MOT), Natural Bond Orbital (NBO), and Energy ...
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nature CommunicationsNon-dissociative chemisorption solid-state storage of hydrogen molecules in host materials is promising to achieve both high hydrogen capacity and uptake rate, but there is the lack of non-dissociative hydrogen storage theories that can guide the ...
Yong Gao +18 more
doaj +1 more source
Image Analysis and StereologyUAV photogrammetry constitutes a fundamental technology for the lifecycle maintenance and digital twin construction of large-scale transport infrastructure.
Xiaocong Jiang, Tian Yang Luo
doaj +1 more source