Results 51 to 60 of about 1,051,029 (290)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Computational Nutraceutics: Chemical Reactivity Properties of the Flavonoid Naringin by Means of Conceptual DFT

Journal of Chemistry, 2013
The M06 family of density functionals has been assessed for the calculation of the molecular structure and properties of the Naringin molecule. The chemical reactivity descriptors have been calculated through Conceptual DFT.
Jorge Ignacio Martínez-Araya, Guillermo Salgado-Morán, Daniel Glossman-Mitnik   +2 more
doaj   +1 more source

Ground and excited state similarity studies by means of Fukui and dual-descriptor matrices

Chemical Physics Letters, 2012
Abstract This Letter reports a quantitative study of the similarity between the Fukui matrices corresponding to the ground state and those of the first excited state of a molecular system, as well as between the dual-descriptor matrices of those states. The formulation of the Fukui and dual-descriptor matrices in the basis set representation provides
Alcoba, Diego Ricardo, Lain, Luis, Torre, Alicia, Oña, Ofelia Beatriz, Tiznado, William   +4 more
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Flood Mapping Using Sentinel-1 Dual-Polarimetric SAR Data in Agricultural Landscapes

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Monitoring flood-affected agricultural fields is important because flooding can significantly reduce crop productivity, threatening food security and livelihoods.
Shubhayan Roy Chowdhury, Dipankar Mandal, Abhinav Verma, Gerardo Di Martino, Avik Bhattacharya   +4 more
doaj   +1 more source

An overview of recent developments in computational methods for periodic systems [PDF]

, 2007
: At the First IFAC Workshop on Periodic Systems (Como, Italy, 2001), a state of the art survey of computational methods for periodic systems has been presented (Varga and Van Dooren, 2001).
Andras Varga, Varga, Andreas
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Machine learning-assisted dual-atom sites design with interpretable descriptors unifying electrocatalytic reactions

Nature Communications
Low-cost, efficient catalyst high-throughput screening is crucial for future renewable energy technology. Interpretable machine learning is a powerful method for accelerating catalyst design by extracting physical meaning but faces huge challenges.
Xiaoyun Lin, Xiaowei Du, Shican Wu, Shiyu Zhen, Wei Liu, Chunlei Pei, Peng Zhang, Zhi-Jian Zhao, Jinlong Gong   +8 more
doaj   +1 more source

Application of BI-RADS Descriptors in Contrast-Enhanced Dual-Energy Mammography: Comparison with MRI [PDF]

Breast Care, 2017
Background: Contrast-enhanced (CE) magnetic resonance imaging (MRI) BI-RADS descriptors are used in the evaluation of contrast-enhanced dual-energy mammography (CEDEM) images of mass lesions and are assumed to be applicable. Patients and Methods: Patients with suspicious mass lesions on mammography (BI-RADS 4 or 5) were included.
Thomas, Knogler, Peter, Homolka, Mathias, Hoernig, Robert, Leithner, Georg, Langs, Martin, Waitzbauer, Katja, Pinker, Sabine, Leitner, Thomas H, Helbich   +8 more
openaire   +2 more sources

A numerically reliable approach to robust pole assignment for descriptor systems [PDF]

, 2003
We propose a general, numerically reliable computational approach to solve the pole and eigenstructure assignment problem for descriptor systems. In the multi-input case, the proposed approach addresses the intrinsic non-uniqueness of the pole assignment
A. Varga, Varga, Andras
core