Results 41 to 50 of about 2,309 (216)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Study on the performance and emissions characteristics of reformulated engine blended with producer gas, biogas, and pongamia pinnata biodiesel

Next Sustainability
This paper presents the performance and emission analysis of a compression ignition dual-fuel engine using various fuel blends made from Karanja biodiesel (BD), biogas (BG), and producer gas (PG).
Praveen Kumar, Aman Kumar Pal
doaj   +1 more source

Experimental Study on Fuel-Switching of Dual-Fuel Gas Turbine Combustor

Frontiers in Energy Research, 2022
To research the fuel-switching rules for gas turbine dual-fuel combustor, the effects of fuel change rate, fuel compensation rate, permissible fluctuation limit of outlet temperature, and fuel matching on the fuel-switching performance were studied ...
Lin Feng, Yang Qiang, Liu Xiao, LI Ming-jia, Ran Jun-hui, Li Ya-jun   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Experimental Investigation Of Biogas-Biodiesel Dual Fuel Combustion In A Diesel Engine

Journal of Middle European Construction and Design of Cars, 2015
This study is an attempt at achieving diesel fuel equivalent performance from diesel engines with maximum substitution of diesel with renewable fuels. In this context the study has been designed to analyze the influence of B20 algae biodiesel as a pilot ...
Ramesha D. K., Bangari Adhiviraj Singh, Rathod Chirag P., Samartha Chaitanya R.   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research on Calibration, Economy and PM Emissions of a Marine LNG–Diesel Dual-Fuel Engine

Journal of Marine Science and Engineering, 2022
In order to convert the marine diesel engine into an LNG (Liquefied Natural Gas)–diesel dual-fuel engine and ensure its power and emission characteristics, a new calibration method is proposed, and the fuel substitution ratio, economy and detailed ...
Beidong Zhang, Yankun Jiang, Yexin Chen
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source