Results 41 to 50 of about 38,591 (266)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CNG-diesel dual fuel engine: A review on emissions and alternative fuels [PDF]

open access: yes2015 10th Asian Control Conference (ASCC), 2015
This review paper is focusing on the investigations and studies on emissions of applying the Compressed Natural Gas (CNG) in the CNG-Diesel engines. As well as, the paper is highlighting studies that involved in the search for alternative fuels to be used for less emissions and good performance vehicles. Moreover, illustrating the developments occurred
Abdulwahab A. Abdulrahman Al-Saadi   +1 more
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Innovative Survey on Dual Fuel Engine with Fuel Essences [PDF]

open access: yesInternational Journal of High Energy Physics, 2017
Alternative fuels have been getting more attention as concerns escalate over exhaust pollutant emissions produced by internal combustion engines, higher fuel costs, and the depletion of crude oil. Various solutions have been proposed, including utilizing alternative fuels as a dedicated fuel in spark ignited engines, diesel pilot ignition engines, gas ...
openaire   +1 more source

Experimental Investigation Of Biogas-Biodiesel Dual Fuel Combustion In A Diesel Engine

open access: yesJournal of Middle European Construction and Design of Cars, 2015
This study is an attempt at achieving diesel fuel equivalent performance from diesel engines with maximum substitution of diesel with renewable fuels. In this context the study has been designed to analyze the influence of B20 algae biodiesel as a pilot ...
Ramesha D. K.   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Research on Calibration, Economy and PM Emissions of a Marine LNG–Diesel Dual-Fuel Engine

open access: yesJournal of Marine Science and Engineering, 2022
In order to convert the marine diesel engine into an LNG (Liquefied Natural Gas)–diesel dual-fuel engine and ensure its power and emission characteristics, a new calibration method is proposed, and the fuel substitution ratio, economy and detailed ...
Beidong Zhang, Yankun Jiang, Yexin Chen
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Optimization of Fuel Supply Strategy for LNG Dual-fuel Ships

open access: yesJournal of Physics: Conference Series, 2023
Abstract Fuel cost is an important part of voyage cost, and fuel replenishment strategy is an important decision affecting the operating cost and benefit of shipping companies. A mixed integer nonlinear programming model of fuel supply for LNG dual-fuel ships is established to expand the research scope of fuel supply in the shipping ...
Shuting Li, Pengshi Zhang, Zhuo Sun
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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