Results 221 to 230 of about 1,163,674 (252)

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Development and validation of a multimodal predictive model based on clinical, biochemical, and quantitative dual-energy CT parameters: for predicting the benignity and malignancy of thyroid nodules. [PDF]

Front Endocrinol (Lausanne)
Zhang Y, Yin C, Huang R, Zhang G, Pan X.
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Adrenocortical Carcinoma with Suspected Dual Cortisol and Aldosterone Secretion: A Case Report. [PDF]

J ASEAN Fed Endocr Soc
Jaime CF, Gan FR.
europepmc   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Breast tubular adenoma: diagnostic challenges and management insights from a six-case series. [PDF]

J Surg Case Rep
Ng WR, Pellegrino S, Macindoe C, Shamassi M, Zadeh HS, To H.   +5 more
europepmc   +1 more source

Glucagon-Like Peptide-1 (GLP-1)-Based Therapies and Hematological Malignancies: A Narrative Review of Current and Emerging Evidence. [PDF]

Cureus
Krishnan Nair H.
europepmc   +1 more source

Holistic Management of Obesity in Patients with Incidental Cancer After Unprovoked Deep Vein Thrombosis: A Cardiometabolic and Antithrombotic Framework. [PDF]

Cancers (Basel)
Geraci C, Cannarella R, Morello V, Paternò V, Petrina SM, Esposito R, Geraci G, Condorelli RA, La Vignera S, Calogero AE.   +9 more
europepmc   +1 more source

RCAF for patient-level thyroid ultrasound malignancy prediction under leakage-free evaluation and calibration. [PDF]

Sci Rep
Sherif M, Elsayed EK, Deif MA.
europepmc   +1 more source