Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Eating behaviors and nutritional habits among young adults using electronic nicotine delivery systems in a multinational cross-sectional study. [PDF]
Saleh SM +7 more
europepmc +1 more source
A denominator identity for affine Lie superalgebras with zero dual Coxeter number
Gorelik, M., Reif, S.
core +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Contrastive learning-enhanced personalized interaction dual tower network for recommendation. [PDF]
Yang F, Wang B, Li P.
europepmc +1 more source
Reply to Comment on ‘A new method to measure electron density and effective atomic number using dual-energy CT images’ [PDF]
Luis Ramos +2 more
openalex +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Spatial-temporal characteristics and driving factors of the coupling coordination between primary health care and socioeconomic development: a case study of Beijing, China. [PDF]
Liu H, Ma C, Lv S, Tong Z.
europepmc +1 more source

