Results 201 to 210 of about 2,894,253 (306)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Optimized dual NURBS curve interpolation for high-accuracy five-axis CNC path planning. [PDF]

Sci Rep
Xu Y, Zaman MHM, Zhou F.
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Photon-Number Conserved Universal Quantum Logic Employing Continuous-Time Quantum Walk on Dual-Rail Qubit Arrays [PDF]

Hao–Yu Guan, Yifei Li, Xiu–Hao Deng
openalex   +3 more sources

A Multi-sensor Gait Dataset Collected Under Non-standardized Dual-Task Conditions. [PDF]

Sci Data
Liao Y, Cao J, Yu L, Xiang J, Zhao Y.
europepmc   +1 more source

On the Dual Number in the Manuscript Collection of Sermons by Jurgis Ambroziejus Pabrėža

Jūratė Pajėdienė
openalex   +1 more source

Discussion: “Displacement Analysis of Spatial Five-Link Mechanisms Using (3×3) Matrices With Dual-Number Elements” (Yang, A. T., 1969, ASME J. Eng. Ind., 91, pp. 152–156) [PDF]

, 1969
Ravindra Kumar Gupta
openalex   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Performance and Emission Analysis of a Biogas-Diesel Dual-Fuel Engine Enhanced with Diethyl Ether Additives. [PDF]

ACS Omega
Walle M, Yeneneh K, Sufe G, Fetene BN.
europepmc   +1 more source