Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Five Years On and Still in Motion: A Retrospective Analysis of the Five-Year Survivorship of Dual Mobility Total Hip Arthroplasty Performed for Diverse Indications. [PDF]
CureusRout S, Chauhan S, Rout S.
europepmc +1 more source
Duality in Bipolar Fuzzy Number Linear Programming Problem [PDF]
, 2019 Reza Ghanbari +2 more
openalex +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Exploring outcomes between single and dual caregiver households participating in a parenting and family strengthening intervention in Rwanda: the case of Sugira Muryango. [PDF]
BMC Public HealthUkwishaka J +3 more
europepmc +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Comparative dosimetric evaluation of single-beam dual-arc <i>versus</i> dual-beam single-arc volumetric modulated arc therapy strategies in lung stereotactic body radiotherapy using Monaco. [PDF]
PeerJDing J, Huang Y, Li Q, Chen W, Shao K.
europepmc +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Dual-energy CT multiparametric analysis improves diagnostic accuracy and reduces complications in percutaneous transthoracic needle biopsy. [PDF]
Quant Imaging Med SurgYao J +5 more
europepmc +1 more source