Results 101 to 110 of about 369,263 (302)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Dual Quaternion Functions and Its Applications

open access: yesJournal of Applied Mathematics, 2013
A dual quaternion is associated with two quaternions that have basis elements e0, e1, e2, e3, and ε. Dual numbers are often written in the form z=ζ+εζ*, where ε is the dual identity and has the properties ε2=0  (ε≠0).
Su Jin Lim, Kwang Ho Shon
doaj   +1 more source

Dual-Complex Numbers And Their Holomorphic Functions

open access: yesviXra, 2013
The purpose of this paper is to contribute to development a general theory of dual-complex numbers. We start by de…ne the notion of dual- complex and their algebraic properties. In addition, we develop a simple mathematical method based on matrices, simplifying manipulation of dual-complex numbers.
openaire   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Parabolic Numbers: A New Perspective

open access: yesJournal of New Theory
Thus far, many studies have been conducted on $p$-complex numbers. Depending on the sign of $p$, there are three cases: hyperbolic, dual, and elliptic. In the literature, dual numbers are called parabolic numbers, but they do not parameterize parabolas ...
Furkan Semih Dündar
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

A Hyper-Dual Number Approach to Higher-Order Derivative Computation

open access: yesAxioms
This paper develops a theoretical framework for the computation of higher-order derivatives based on the algebra of hyper-dual numbers. Extending the classical dual number system, hyper-dual numbers provide a natural and rigorous mechanism for encoding ...
Ji Eun Kim
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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