Results 121 to 130 of about 622,232 (309)

Dual-Phase Molecular-like Charge Transport in Nanoporous Transition Metal Oxides

, 2019
The conductivity of porous films in the presence of a large concentration of electrolyte is modeled considering two behaviors: “molecular-like” behavior corresponding to a single electrical phase with localized redox species surrounded by an electrolyte ...
Daniel G. Nocera (1341363), Cyrille Costentin (1499620)   +1 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Novel polarization-assisted phase sensitive optical signal processor requiring low nonlinear phase shifts

We demonstrate a new scheme to achieve binary step-like phase response and high phase-sensitive extinction ratio at low powers. Phase-sensitive operation is achieved by polarization filtering phase-locked signal/idler in a degenerate dual-pump vector ...
Horak, P., Hesketh, G., Parmigiani, F., Slavík, R., Petropoulos, P., Richardson, D.J.   +5 more
core  

Dual-Phase Neural Networks for Feature Extraction and Ensemble Learning for Recognizing Human Health Activities

The integration of smart devices into healthcare has led to the creation of vast amounts of sensor data, which are crucial for advancing various healthcare applications such as elderly care, lifestyle enhancement, and health monitoring.
Goyal, Puneet, Mishr, Sudeepta, Mistry, Sajib, Dhar, Joy, Rana, Rajib, Vo, Bao Quoc, Alavi, Azadeh, Rana, Kapil   +7 more
core   +1 more source

Design of BCC/FCC dual-solid solution refractory high-entropy alloys through CALPHAD, machine learning and experimental methods

npj Computational Materials
Refractory high-entropy alloys (RHEAs) typically exhibit a body-centered cubic (BCC) structure with excellent strength but poor ductility, which limits their practical applications.
Longjun He, Chaoyue Wang, Mina Zhang, Jinghao Li, Tianlun Chen, Xianglin Zhou   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CFD Simulation and Experimental Study on Single Phase Dual Temperature Ejector

, 2012
An adjust ejector was designed based on classical gas dynamical function method in single phase dual temperature ejector refrigeration system. Further more ejector optimal dimension influenced by mass flow distribution ratio, high and low evaporating ...
Zhuang, Rong, Zheng, Bo, Liang, Xiangfei, Wu, Yingwen   +3 more
core  

Dual-phase-modulated plug-and-play measurement-device-independent continuous-variable quantum key distribution

, 2018
We suggest an improved plug-and-play measurement-device-independent (MDI) continuous-variable quantum key distribution (CVQKD) via the dual-phase modulation (DPM), aiming to solve an implementation problem with no extra performance penalty.
Yijun Wang (321141), Duan Huang (5785016), Qin Liao (627108), Ying Guo (53523)   +3 more
core   +1 more source