Results 121 to 130 of about 1,808,891 (305)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

High creep resistance in amorphous/crystalline dual-phase nanostructured CoCrFeNiMn high entropy alloys

Journal of Materials Research and Technology
Amorphous/crystalline dual-phase metallic materials received great attention owing to their synergistic combination of strength and ductility. However, the mechanisms governing creep deformation in these dual-phase materials are largely elusive.
Lili Xiao, Kai Sun, Wengao Pan, Juan Du, Zhaojie Meng, Xinwen Zhang, Shaolin Li, Pengfei Yue, Guoshang Zhang, Kejia Kang   +9 more
doaj   +1 more source

Phase Transitions in Warped AdS$_3$ Gravity

, 2015
We consider asymptotically Warped AdS$_3$ black holes in Topologically Massive Gravity. We study their thermodynamic stability and show the existence of a Hawking-Page phase transition between the black hole and thermal background phases. At zero angular
Detournay, Stéphane, Zwikel, Céline
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A disorder parameter for dual superconductivity in gauge theories

, 1997
Dual superconductivity in the confining phase of gauge theories is discussed in terms of a disorder parameter which vanishes in normal phase and is different from zero in the superconducting phase.Comment: 3 pages, 4 postscript figures, espcrc2, epsfig ...
A. Di Giacomo, Abrikosov, B. Lucini, Caselle, Creutz, Del Debbio, Di Cecio, Di Giacomo, G. Paffuti, Greensite, Haymaker, Hooft, Hooft, L. Montesi, Mandelstam, Singh   +15 more
core   +2 more sources

Holographic Duals of Symmetry Broken Phases

Fortschritte der Physik
AbstractA novel interpretation of Symmetry Topological Field Theories (SymTFTs) as theories of gravity is explored by proposing a holographic duality where the bulk SymTFT (with the gauging of a suitable Lagrangian algebra) is dual to the universal effective field theory (EFT) that describes spontaneous symmetry breaking on the boundary.
Antinucci, Andrea, Benini, Francesco, Rizi, Giovanni   +2 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Dual-Band Tunable Recursive Active Filter

, 2011
This letter presents a novel recursive active filter topology that provides dual-band performance, with independent tuning capability in both bands. The dual-band operation is achieved by using two independent feedback lines.
Aznar Ballesta, Francisco, García Pérez, Oscar Alberto, González Posadas, Vicente, Segovia Vargas, Daniel   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Design of BCC/FCC dual-solid solution refractory high-entropy alloys through CALPHAD, machine learning and experimental methods

npj Computational Materials
Refractory high-entropy alloys (RHEAs) typically exhibit a body-centered cubic (BCC) structure with excellent strength but poor ductility, which limits their practical applications.
Longjun He, Chaoyue Wang, Mina Zhang, Jinghao Li, Tianlun Chen, Xianglin Zhou   +5 more
doaj   +1 more source