Results 101 to 110 of about 982,655 (280)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The algebraic structure of dual semi-quaternions
, 2016 http://www.josunas.org/login/index.php/josunas/article/view/596We introduce the dual semi-quaternions algebra, Hds, and study some fundamental algebraic properties of them. We show that the set of unit dual semi-quaternions is a subgroup of Hds.
Jafari, Mehdi
core
An introduction to using dual quaternions to study kinematics [PDF]
, 2023 We explain the use of dual quaternions to represent poses, twists, and wrenches.Comment: Addition of references.
Montgomery-Smith, Stephen, Shy, Cecil
core
Optimizing Motion Sequences with Projective Dual Quaternions
AppliedMathThis paper builds upon a previous study suggesting an optimization procedure for rotation sequences by introducing a fourth factor in Euler-type decompositions, thus allowing for an additional degree of freedom used both as a variational parameter and a ...
Danail Brezov
doaj +1 more source
Advanced quaternion forward kinematics algorithm including overview of different methods for robot kinematics [PDF]
FME Transactions, 2014 Formulation of proper and efficient algorithms for robot kinematics is essential for the analysis and design of serial manipulators. Kinematic modeling of manipulators is most often performed in Cartesian space.
Vidaković Jelena Z. +4 more
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Research on the rigid body pose estimation using dual quaternions
Advances in Mechanical Engineering, 2019 The dual quaternion is the simplest and most effective mathematical tool to describe the translational and rotational motion of a general rigid body. Its computation and updating require screw vector. The relative pose information need to be updated when
Jing Li
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source