Results 121 to 130 of about 2,080 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On Dual Quaternions, Dual Split Quaternions and Cartan-Schouten Metrics on Perfect Lie Groups

We discuss Cartan-Schouten metrics (Riemannian or pseudo-Riemannian metrics that are parallel with respect to the Cartan-Schouten canonical connection) on perfect Lie groups. Applications are foreseen in Information Geometry. Throughout this work, the tangent bundle TG and the cotangent bundle T*G of a Lie group G, are always endowed with their Lie ...
André Diatta, Bakary Manga, Fatimata Sy
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Dual Quaternion-Based Dynamic Modeling and Adaptive Neural Identification for Load-Assist Exoskeletons

IEEE Access
This article addresses the challenge of modeling and controlling load-assist exoskeletons operating under dynamic and uncertain conditions. Traditional approaches often rely solely on dual quaternions for kinematic modeling, limiting their applicability ...
Angel Eduardo Zamora-Suarez, Fermin Castillo Anaya, Pamela Patricia Vera-Tizatl, Rosalio Reyes   +3 more
doaj   +1 more source

Dual Quaternion-Based Powered Descent Guidance with State-Triggered Constraints [PDF]

, 2020
Taylor P. Reynolds, Michael Szmuk, Danylo Malyuta, Mehran Mesbahi, Behçet Açıkmeşe, John M. Carson   +5 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Análise cinemática via quatérnios duais aplicada a um sistema veículo-manipulador subaquático [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Automação e Sistemas, Florianópolis, 2011Este trabalho propõe metodologias para a análise cinemática de sistemas veículo-manipulador
Oliveira, André Schneider de
core  

A dual quaternion algorithm of the Helmert transformation problem [PDF]

, 2018
Huaien Zeng, Xing Fang, Guobin Chang, Ronghua Yang   +3 more
openalex   +1 more source

Unit dual quaternion based tracking control with velocity saturations applied on quadrotor

, 2023
Wenxin Hu, Wang Yajing, Xiangke Wang
openalex   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source