Results 91 to 100 of about 3,875,475 (226)

Dual sensory loss and cognitive performance among older adults in India

Journal of Alzheimer’s Disease
Background Hearing loss (HL) and vision loss (VL) occur frequently among older adults and are independent risk factors for dementia, including in low- and middle-income countries (LMICs), where incident dementia is common.
Clarice A Myers, Wuyang Zhang, Niranjani Nagarajan, Jinkook Lee, AB Dey, Sharmistha Dey, Joyita Banerjee, Pranali Khobragade, Anushikha Dhankhar, Nicholas S Reed, Joshua R Ehrlich   +10 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dual sensory impairment in older adults increases the risk of mortality: a population-based study.

PLoS ONE, 2013
Although concurrent vision and hearing loss are common in older adults, population-based data on their relationship with mortality is limited. This cohort study investigated the association between objectively measured dual sensory impairment (DSI) with ...
Bamini Gopinath, Julie Schneider, Catherine M McMahon, George Burlutsky, Stephen R Leeder, Paul Mitchell   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Participation experiences of people with deafblindness or dual sensory loss: A scoping review of global deafblind literature.

PLoS ONE, 2018
BackgroundDeafblindness, also known as dual sensory loss, is a varying combination of visual and hearing impairment in the same individual. Interest in this topic has increased recently due to evidence suggesting an increase in prevalence of this ...
Atul Jaiswal, Heather Aldersey, Walter Wittich, Mansha Mirza, Marcia Finlayson   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Dual sensory loss and cognitive decline: evidence from the EpiFloripa Aging study

The aim of this study was to determine the association between dual sensory loss (hearing and vision) and cognitive decline in older adults living in the South of Brazil.
Thamara Hubler Figueiró, Eleonora d’Orsi, Ana Luiza Curi Hallal, Danúbia Hillesheim, Anna Quialheiro, Viviane Nogueira de Zorzi   +5 more
core   +1 more source

Some memories are odder than others : Judgments of episodic oddity violate known decision rules [PDF]

, 2011
Current decision models of recognition memory are based almost entirely on one paradigm, single item old/new judgments accompanied by confidence ratings.
Ian G. Dobbins, Dobbins, Ian, Emily N. Guhl, O'Connor, Akira Robert, Akira R. O’Connor, Justin C. Cox, Cox, Justin, Guhl, Emily   +7 more
core   +1 more source

Children with Usher syndrome: mental and behavioral disorders

Behavioral and Brain Functions, 2012
Background Mental and behavioral disorders among adults with Usher syndrome have been discussed and reported in some case studies but no research has been reported on children with Usher syndrome.
Dammeyer Jesper
doaj   +1 more source