Results 71 to 80 of about 327,523 (273)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Combined Vision and Hearing Impairment is Associated with Frailty in Older Adults: Results from the West China Health and Aging Trend Study

Clinical Interventions in Aging, 2022
Yanli Zhao, Qunfang Ding, Taiping Lin, Xiaoyu Shu, Dongmei Xie, Langli Gao, Jirong Yue Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, People’s Republic of ...
Zhao Y, Ding Q, Lin T, Shu X, Xie D, Gao L, Yue J   +6 more
doaj  

Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease

EMBO Molecular Medicine, 2023
Deafness affects 5% of the world's population, yet there is a lack of treatments to prevent hearing loss due to genetic causes. Norrie disease is a recessive X‐linked disorder, caused by NDP gene mutation.
Valda Pauzuolyte, Aara Patel, James R Wawrzynski, Neil J Ingham, Yeh Chwan Leong, Rajvinder Karda, Maria Bitner‐Glindzicz, Wolfgang Berger, Simon N Waddington, Karen P Steel, Jane C Sowden   +10 more
doaj   +1 more source

Semantic Compression of Episodic Memories [PDF]

, 2018
Storing knowledge of an agent's environment in the form of a probabilistic generative model has been established as a crucial ingredient in a multitude of cognitive tasks. Perception has been formalised as probabilistic inference over the state of latent
Nagy, David G., Orbán, Gergő, Török, Balázs   +2 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Audiological phenotype of siblings with dual sensory impairment caused by SLITRK6 mutation—case report

The Egyptian Journal of Otolaryngology
Background Dual sensory impairment (DSI), defined as concomitant hearing and vision loss, is a rare but clinically significant condition. While genetic factors account for the majority of congenital sensory impairments, dual impairment syndromes are less
Swapna Sebastian, Paul Jasper, Manju Deena Mammen, Ann Mary Augustine   +3 more
doaj   +1 more source

Departure from the onset-onset rule [PDF]

, 1994
Using a signal-detection task, the generality of Turvey's (1973) onset-onset rule was tested in four experiments. After seeing, in succession, (1) one or two letters (target display), (2) a multiletter detection display, and (3) a mask display, subjects ...
Chow, Siu
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Underwater Image Enhancement Based on Generative Adversarial Networks

Shanghai Jiaotong Daxue xuebao, 2022
This paper proposes an underwater image correction and enhancement algorithm based on generative adversarial networks. In this algorithm, the multi-scale kernel is applied to the improved residual module to construct a generator, which realizes the ...
LI Yu, YANG Daoyong, LIU Lingya, WANG Yiyin
doaj   +1 more source

EXAMINING QUALITY INDICATOR RATES FOR OLDER HOME CARE CLIENTS WITH DUAL SENSORY IMPAIRMENT (DSI) AND EXPLORING THE HETEROGENEITY WITHIN DSI. [PDF]

, 2016
Older adults with impairments in both hearing and vision, called dual sensory impairment (DSI), are at an increased risk of negative health outcomes such as impaired communication and difficulties with mobility.
Davidson, Jacob G S, Guthrie, Dawn M.
core   +1 more source