Results 81 to 90 of about 7,745,562 (335)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Analytic semigroups generated by an operator matrix in L^2(Omega) X L^2(Omega)

Electronic Journal of Differential Equations, 2012
This article concerns the generation of analytic semigroups by an operator matrix in the space $L^2(Omega)imes L^2(Omega)$. We assume that one of the diagonal elements is strongly elliptic and the other is weakly elliptic, while the sum of the non ...
Salah Badraoui
doaj  

Financial Decisions Based on Zero-Sum Games: New Conceptual and Mathematical Outcomes

International Journal of Financial Studies
All the n possible returns on a financial asset are the components of an element of a linear space over R. This paper shows how to transfer all these n possible returns on a one-dimensional straight line.
Pierpaolo Angelini
doaj   +1 more source

SU(2) Calorons and Magnetic Monopoles

, 1998
We investigate the self-dual Yang-Mills gauge configurations on $R^3\times S^1$ when the gauge symmetry SU(2) is broken to U(1) by the Wilson loop. We construct the explicit field configuration for a single instanton by the Nahm method and show that an ...
A.A. Belavin, B.J. Harrington, Changhai Lu, D. Gross, E. Corrigan, E.J. Weinberg, G. ’t Hooft, H. Garland, H. Nakajima, J.P. Gauntlett, J.P. Gauntlett, K. Lee, K. Lee, K. Lee, K. Lee, K. Lee, Kimyeong Lee, M.F. Atiyah, N.H. Christ, N.J. Hitchin, P. Rossi, R. Jackiw, T.C. Kraan, W. Nahm, W. Nahm   +24 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The dual of a space of compact operators

AIMS Mathematics
Let $ X $ and $ Y $ be Banach spaces. We provide the representation of the dual space of compact operators $ K(X, Y) $ as a subspace of bounded linear operators $ \mathcal{L}(X, Y) $.
Keun Young Lee , Gwanghyun Jo
doaj   +1 more source

Characterization of triple χ3 sequence spaces via Orlicz functions [PDF]

Mathematica Moravica, 2016
In this paper we study of the characterization and general properties of triple gai sequence via Orlicz space of χ3 M of χ3 establishing some inclusion relations.
Subramanian N., Esi A.
doaj  

Self-duality and vacuum selection

, 2004
I propose that self-duality in quantum phase-space provides the criteria for the selection of the quantum gravity vacuum. The evidence for this assertion arises from two independent considerations.
ALON E. FARAGGI, Antoniadis I., Antoniadis I., Cleaver G. B., Dedes A., Donagi R., Elitzur S., Faraggi A. E., Faraggi A. E., Faraggi E. A., Ginsparg P., Giveon A., Green M. B.   +12 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

On β-dual of vector-valued sequence spaces of Maddox

International Journal of Mathematics and Mathematical Sciences, 2002
The β-dual of a vector-valued sequence space is defined and studied. We show that if an X-valued sequence space E is a BK-space having AK property, then the dual space of E and its β-dual are isometrically isomorphic.
Suthep Suantai, Winate Sanhan
doaj   +1 more source