Results 71 to 80 of about 664,193 (303)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Dual Labor Market and Endogenous Fluctuations [PDF]
We study the influence of wage differential on the emergence of endogenous fluctuations. In this way, we introduce a dual labor market, based on the Shapiro-Stiglitz efficiency wage theory in an overlapping generations model. We show that wage inequality
Thomas Seegmuller, Francesco De Palma
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Dual-Function Electrochromic Supercapacitors Displaying Real-Time Capacity in Color [PDF]
, 2018 Dual-function electrochromic supercapacitors (ECSs) that indicate their real-time charge capacity in color are fabricated using tungsten trioxide (WO3) and Li-doped ion gels containing hydroquinone (HQ).
Se Hyun Kim (1426993) +7 more
core +3 more sources
Research on UAV network slicing resource management for low-altitude intelligent network
Dianxin kexueIn low-altitude intelligent networks, unmanned aerial vehicles (UAV) play a crucial role as aerial communication base stations, data relay nodes, and mobile network terminals. Leveraging their exceptional mobility and adaptability, UAV can extend network
CHEN Hongjie +4 more
doaj
Local-Global and Multi-Scale (LG-MS) Mixer Architecture for Long-Term Time Series Forecasting
IEEE AccessAlthough deep learning models dominate time series forecasting, they still struggle with long-sequence processing due to the challenges of extracting dynamic fluctuations and pattern features as input length increases.
Zhennan Peng +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A dual-scale modelling approach for drying hygroscopic porous media [PDF]
, 2013 A new dualscale modelling approach is presented for simulating the drying of a wet hygroscopic porous material that couples the porous medium (macroscale) with the underlying pore structure (microscale).
Carr, E. J. +4 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source