Results 91 to 100 of about 664,193 (303)

Investigating underlying brain structures and influence of mild and subjective cognitive impairment on dual-task performance in people with Parkinson’s disease

Scientific Reports
Cognitive impairment can affect dual-task abilities in Parkinson’s disease (PD), but it remains unclear whether this is also driven by gray matter alterations across different cognitive classifications.
Franziska Albrecht, Hanna Johansson, Urban Ekman, Konstantinos Poulakis, Lucian Bezuidenhout, Joana B. Pereira, Erika Franzén   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The present location of temporal embeddedness: the case of time linked consumption practices in dual career families [PDF]

, 2009
This paper examines the time linked consumption practices of professional dual career families, examining the kind of consumption practices these families use to manage their lives.
Bettany, S., Gatrell, C.
core  

Converses of nabla Pachpatte-type dynamic inequalities on arbitrary time scales

Demonstratio Mathematica
Reverse Pachpatte-type inequalities are concave generalizations of the well-known Bennett-Leindler-type inequalities. We establish reverse nabla Pachpatte-type dynamic inequalities taking account of concavity.
Kayar Zeynep, Kaymakçalan Billur
doaj   +1 more source

State of charge estimation method for lithium-ion battery pack using BP-MDM-TEM

Frontiers in Energy Research
Addressing the fluctuating core temperatures during series battery pack operation that cause inconsistency in pack battery characteristics, the paper introduces a Battery-Pack Mean Difference-Method With Thermal-Electrical Coupled Model (BP-MDM-TEM ...
Haiyan Yao, Yuefei Xu, Qiang Guo, Yufeng Miu, Xufeng Zhang, Jiadong Wei, Yunning Zhang, Chunshi Wang   +7 more
doaj   +1 more source

Thermodynamic modeling, energy equipartition, and nonconservation of entropy for discrete-time dynamical systems

Advances in Difference Equations, 2005
We develop thermodynamic models for discrete-time large-scale dynamical systems. Specifically, using compartmental dynamical system theory, we develop energy flow models possessing energy conservation, energy equipartition, temperature equipartition, and
Vijaysekhar Chellaboina, Sergey G. Nersesov, Qing Hui, Wassim M. Haddad   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Investigation of the speed-up of a dual microcontroller parallel processing system in the execution of a mathematical operation [PDF]

An investigation of the performance of a two microcontroller parallel processing system is presented. A twomicrocontroller parallel processing is developed using low end microcontrollers (PIC 16F877).
Ng, Wai Pang, Harrington, Peter
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source