Results 101 to 110 of about 664,193 (303)

Detecting response styles by using dual scaling of successive categories [PDF]

A response style denotes a certain mapping of latent preferences toa rating scale that is common among a certain group of individuals.For example, individuals from the same country may assign highratings to the majority of objects regardless of the ...
Velden, M. van de
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Long-Time Coherent Integration for the Spatial-Based Bistatic Radar Based on Dual-Scale Decomposition and Conditioned CPF

Remote Sensing
This paper addresses the problem of weak maneuvering target detection in the space-based bistatic radar system through long-time coherent integration (LTCI).
Suqi Li, Yihan Wang, Yanfeng Liang, Bailu Wang   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

CDAM-Net: Channel shuffle dual attention based multi-scale CNN for efficient glaucoma detection using fundus images [PDF]

Glaucoma is a typical eye disorder that induces damage to the optic nerve due to increased intraocular pressure. It ultimately leads to partial or complete blindness without clinical reversal.
Das, Dipankar, Bhandary, Sulatha V., Acharya, U. Rajendra, Nayak, Deepak Ranjan   +3 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Scale effects, time-varying markups, and the cyclical behaviour of primal and dual productivity [PDF]

This paper presents estimates of the degree of returns to scale using nonparametric measures of primal and dual productivity for 2-digit US manufacturing industries. As part of the analysis, the cyclical behaviour of primal and dual productivity measures
Alpay Filiztekin, Sumru Altug
core   +1 more source

The Impact of Dual-Career Support Systems on Perceived Barriers Among European Student-Athletes with Disabilities

Education Sciences
The aim of this study was to compare the socio-demographic, sporting characteristics and perceptions of student-athletes with disabilities of perceived barriers according to the state system of dual career support. Two hundred and twelve student-athletes
Alejandro Leiva-Arcas, Raquel Vaquero-Cristóbal, Lourdes Meroño, María José Maciá-Andreu, Juan Alfonso García-Roca, Lucía Abenza-Cano, Antonino Manuel Almeida-Pereira, Laura Capranica, Tom Comyns, Aura Bota, Amaia Ramírez-Muñoz, Luis Maicas-Pérez, Emanuele Isidori, Antonio Sánchez-Pato   +13 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source