Results 111 to 120 of about 16,914,292 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Optimal Grazing Termination Date for Dual-Purpose Winter Wheat Production [PDF]

Dual-purpose winter wheat (fall-winter forage plus grain) production is an important economic enterprise in the southern Great Plains. Grazing termination to enable grain production is a critical decision.
Fieser, Brian G., Horn, Gerald W., Brorsen, B. Wade, Taylor, Karen W., Epplin, Francis M.   +4 more
core  

Development of a New Mechanism for Dual Rotary Compressor [PDF]

, 2012
After the Great East Japan Earthquake, it is an urgent necessity for us to cut down the vain use of the power. Beforehand we have proposed the reduction of the power consumption used in “actual” air-conditioner operating load is low, and we have produced
Monasry, Jafet, Hirano, Koji
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Impact of Differing Definitions of Dual Tobacco Use: Implications for Studying Dual Use and a Call for Operational Definitions

, 2011
Introduction: Concomitant use of two forms of tobacco is an increasing public health concern, yet there is little consensus regarding a consistent definition of so-called "dual use." We defined dual use as cigarette and smokeless tobacco (ST) consumption
DeBon, Margaret, Talcott, Wayne G, Morgan, Glen D, Deborah Sherrill-Mittleman, Wayne G. Talcott, Jon O. Ebbert, Robert C. Klesges, Sherrill-Mittleman, Deborah, Margaret DeBon, Taghrid Asfar, Ebbert, Jon O, Asfar, Taghrid, Glen D. Morgan, Klesges, Robert C   +13 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dual-class stock structure and firm investment

, 2022
Dual-class stock structure helps insiders gain control through different voting rights, but also exacerbates the principal-agent conflict. The separation of control rights and cash flow rights enhances managerial opportunistic behavior. We find that dual-
Ruicheng Zhu (20083161), May Hu (13809892), Jingjing Yang (119262), Hamid Beladi (13349718)   +3 more
core  

Comparative effects of cigarette smoking, e-cigarette use, and dual use on pulmonary function, exercise capacity, and quality of life in young adults: a cross-sectional study

Frontiers in Public Health
BackgroundTobacco smoking constitutes a primary cause of preventable cardiovascular and pulmonary diseases on a global scale. While smoking rates fall, e-cigarette use rises, especially in youth.ObjectiveAssess effects of smoking, vaping, and dual use on
Gokul G. Krishna, Ann M. Jose, Weaam A. Rahali, Wejdan W. Alyamani, Manahel A. Mohammed, Basmah S. Alghamdi, Mazen M. Homoud, Mohammed Almeshari, Mohammed Almeshari, Khalid S. Alwadeai, Saleh R. Alkhathami, Jithin K. Sreedharan, Ayedh D. Alahmari   +12 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The association between health literacy and e-cigarette use: evidence from Zhejiang, China

Frontiers in Public Health
ObjectivesThe worldwide popularity of electronic cigarettes (ECIG) is becoming a public health concern. Compared to conventional cigarettes (CIG), the harm caused by ECIG is more insidious. Studies have shown that lower health literacy (HL) is associated
Xuehai Zhang, Xinxin Zhang, Songjia Zhang, Lizheng Ge, Yue Xu, Dingning Yao, Xiujing Hu, Zishuo Huang, Tingting Zhu, Zixia Wang, Chun Chen   +10 more
doaj   +1 more source