Results 41 to 50 of about 16,914,292 (257)

E-cigarette-only and dual use among adolescents in Ireland: emerging behaviours with different risk profiles. [PDF]

, 2021
E-cigarette-only use and dual-use are emerging behaviours among adolescent nicotine product users which have not yet been sufficiently explored. This study examines the prevalence of, and the factors associated with, nicotine product use in adolescence ...
Kavanagh , Paul, Paul Kavanagh, Michéal Durcan (10756079), Frank Doyle, O'Donovan, Diarmuid, Emer O'Connell (7941017), Durcan, Michéal, Kavanagh, Paul, Emer O’Connell, Deborah Stanistreet (7899116), Emmet Major (10756082), Frank Doyle (7895504), Diarmuid O’Donovan (4816383), Paul Kavanagh (7898888), Debbi Stanistreet, Diarmuid O’Donovan, Stanistreet, Debbi, Emmet Major, Andrea K. Bowe, Andrea K Bowe (10756076), Doyle, Frank, Michéal Durcan, O'Connell, Emer, Major, Emmet, Bowe, Andrea K, Bowe , Andrea K., Durcan , Michéal, Health Service Executive (HSE)   +27 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Dual use of tobacco and cannabis: significant change in use between Prince Edward Island (PEI) and Canadian students (2008/2009 to 2014/2015)

, 2018
Background Between 2012/2013 and 2014/2015, a significant increase in tobacco and cannabis use occurred among PEI students that did not align with patterns of use in other Canadian provinces.
Melissa Munro-Bernard, Tammy Cumming, Jo-Ann MacDonald, Vicki Rynard, Donna Murnaghan   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mixed mode monolithic sorbent in pipette tip for extraction of ractopamine and clenbuterol prior to analysis by HPLC-UV and UHPLC-Q ExactiveTM Plus Orbitrap MS

Journal of Analytical Science and Technology, 2021
This work developed a fast and simple method for the quantification of two important β-agonists, ractopamine (RAC) and clenbuterol (CLEN) in animal urines.
Kesara Ar-sanork, Chanpen Karuwan, Nakin Surapanich, Prapin Wilairat, Duangjai Nacapricha, Patcharin Chaisuwan   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dual Use PV: Overview and Policy Recommendations [PDF]

Dual-use photovoltaic (PV) technology represents an innovative approach to renewable energy generation, integrating solar panels into existing infrastructure or land already serving other purposes.
Inter-American Development Bank
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Arms Trade Treaty and the Control of Dual-Use Goods and Technologies. IES WORKING PAPER 1/2013 [PDF]

, 2013
This paper seeks to delineate some preliminary factors and working methods that could work in favour of establishing a workable international export control regime for dual-use goods and technologies.
Prizeman, Katherine, Fiott, Daniel
core  

Mechanical characteristics of plane strain unloading conditions with different initial states

Yantu gongcheng xuebao
For the plane strain unloading issues in loess engineering, the lateral unloading plain strain tests on the loess with various initial states (intact, remolded and saturated) under different confining pressures and water contents are carried out by using
ZHANG Yu 1, 2, ZHAO Yang 1, LIU Keji 1, YE Sheng 1, LIU Jin 1, 2, DING Xiao 1, ZHANG Meng 1, QU Yonglong 1
doaj   +1 more source