Results 51 to 60 of about 16,914,292 (257)

Trends in Combustible Cigarette Smoking, Electronic Cigarette Use, and Related Behaviors among Korean Adults: An 11-Year Analysis of Data from the Korea National Health and Nutrition Examination Survey (2013–2023) [PDF]

Tuberculosis and Respiratory Diseases
Background Smoking remains a major preventable cause of death and disease worldwide. The proliferation of electronic cigarettes (e-cigarettes) adds complexity to tobacco control policies. This study analyzed trends in smoking prevalence, e-cigarette use,
Won Jin Yang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

“It Didn't Fill the Void”: reasons for e-cigarette and tobacco dual use

, 2018
Background Although moving from smoking to electronic nicotine delivery systems (ENDS) could reduce the harms smokers face, many ENDS users continue to smoke tobacco. We explored the contributing factors to tobacco use among ENDS users.
Janet Hoek, Rosalina Richards, Lindsay Robertson, Mei-Ling Blank   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization of inclination angle of locking anchor pipe during excavation of upper and middle steps of deeply buried soft rock tunnels

Yantu gongcheng xuebao
In the initial support of soft rock tunnels, the combined support of steel frame and locking foot anchor pipe is an effective and economical support measure to control the deformation of surrounding rock of the tunnels.
DENG Xianghui 1, 2, HE Hailong 1, WANG Rui 1, 2, ZHANG Xuan 1, ZHAO Bangxuan 3, DING Xiao 1, 2
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Maryland Full-Benefit Dual-Eligible Beneficiaries’ Use of Medicare and Medicaid Services Preceding and Following a Medicare Inpatient Stay

, 2016
At the request of the Maryland Department of Health and Mental Hygiene (DHMH), The Hilltop Institute conducted a series of analyses on the health care utilization of Maryland’s full-benefit Medicare-Medicaid dual-eligible beneficiaries.
Stockwell, Ian, Cannon Jones, S.
core   +1 more source

DUAL USE OF TECHNOLOGIES [PDF]

Annals: Series on Military Sciences, 2010
One characteristic of today's society is the existence of dynamic structures with rapid transformations with constant character, for which the necessary time for making decisions has been enormously compressed, the succession turning into simultaneity.
Ion Alexandru PLAVICIOSU
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source