Results 81 to 90 of about 365,287 (261)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Dual-Donor-Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells
Nano-Micro LettersArticle Highlights By modulating the crystalline properties of the active layer with dual donors, the efficiency of organic solar cells reaches 19.23%. The introduction of PTzBI-dF suppresses the accumulation of traps and charge recombination, allowing ...
Anhai Liang +11 more
doaj +1 more source
A new approach to dual-color two-photon microscopy with fluorescent proteins
BMC Biotechnology, 2010 Background Two-photon dual-color imaging of tissues and cells labeled with fluorescent proteins (FPs) is challenging because most two-photon microscopes only provide one laser excitation wavelength at a time. At present, methods for two-photon dual-color
Rebane Aleks +4 more
doaj +1 more source
Defective dual varieties for real spectra [PDF]
Journal of Algebraic Combinatorics, 2018 19 ...
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Crop Breeding and Applied BiotechnologyThis research outlines the development of a specialized cultivar of the opium poppy (Papaver somniferum L.), designed for dual purposes. The primary goal was to breed a variety well-adapted to specific environmental conditions, with a focus on producing ...
Jozef Fejér +3 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Malting quality indicators of Croatian dual-purpose barley varieties
Croatian Journal of Food Science and Technology, 2017 Malting barley varieties usually demand higher expences than feed varieties, at least as far as management practice is concerned. For this reason, many growers in Croatia search for a quality replacement of malting varieties.
Kristina Mastanjević +4 more
doaj +1 more source