Results 61 to 70 of about 365,287 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Associations of Traditional and Peer Cyber-Victimization With Adolescents’ Internet Use: A Latent Profile Analysis

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace, 2019
Significant overlap exists between traditional victimization and peer cyber-victimization. Yet, they can also be somewhat differentiated. Adopting person-centered approaches, studies showed that multiple classes of peer victimization are distinguishable.
Gianluca Gini, Claudia Marino, Jia-Yan Xie, Jan Pfetsch, Tiziana Pozzoli   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The dual complex of a G-variety

Mathematische Zeitschrift
We introduce a new invariant of $G$-varieties, the dual complex, which roughly measures how divisors in the complement of the free locus intersect. We show that the top homology group of this complex is an equivariant birational invariant of $G$-varieties.
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The dual of compact ordered spaces is a variety

Theory and Applications of Categories, 2019
In a recent paper (2018), D. Hofmann, R. Neves and P. Nora proved that the dual of the category of compact partially ordered spaces and monotone continuous maps is a quasi-variety - not finitary, but bounded by $\aleph_1$. An open question was: is it also a variety? We show that the answer is affirmative.
openaire   +5 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dual motorized hexapod singular external fixator frame construct for knee and ankle contracture deformities: A novel technique & case study

Foot & Ankle Surgery: Techniques, Reports & Cases
External fixators can be used in a variety of ways to treat orthopedic pathologies. Fixators have evolved with better understanding of osseous healing and tissue manipulation.
Garrett Wireman, DPM, ATC, Thomas Poynter, DPM, David Seligson, MD, Nicholas Laco, DPM   +3 more
doaj   +1 more source