Results 91 to 100 of about 35,338 (286)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Fair Wage Hypothesis, Foreign Capital Inflow and Skilled-unskilled Wage Inequality in the Presence of Agricultural Dualism [PDF]
The paper develops a four-sector general equilibrium model where the fair wage hypothesis is valid and there is agricultural dualism for analyzing the consequence of an inflow of foreign capital on the skilled-unskilled wage inequality and the ...
Chaudhuri, Sarbajit
core
Гуманитарные и юридические исследования, 2021 The article considers the role and place of Reichstag and meetings of Prince Electors during the Thirty Years’ War. The author underlines that Prince Electors’ meetings promoted the strengthening of their positions in state and political structure of the
Y. E. Ivonin
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A Few Notes on Religious Dualism in the Works of Ramón López Velarde [PDF]
University of Bucharest Review. Literary and Cultural Studies Series, 2015 López Velarde (RLV) has long been regarded as Mexico’s ‘national poet’. Among other important themes, such as the idealization of the Mexican hinterland, his prose and verse are characterized by a very stark dualism: flesh and spirit, Catholic devotion ...
Luis Solis, Celene García
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
TheoRhēma, 2014 The article studies the relationship between theistic evolutionism and the dualistic and sinful aspects of the human nature. This engagement proves essential to Adventist theology, with its particular creationism and anthropology.
Gheorghe Răzmeriță
doaj +2 more sources
The U.S. Imperial Jugger-not: Saturation Points and Cultural Globalization [PDF]
Integral Review, 2010 Globalization is not merely inevitable western cultural conquest. The assumption that the juggernaut of western hegemonic domination will continue until the world is consumed is a common one, but not an accurate one.
Meg Spohn Bertoni
doaj