Results 71 to 80 of about 36,239 (291)

Poverty alleviation programs, FDI-led growth and child labour under agricultural dualism [PDF]

open access: yes
The paper is aimed at providing a theoretical explanation why policies that affect only the supply side of the child labour problem may not be able to mitigate the incidence of child labour in a developing economy in terms of a three-sector general ...
Dwibedi, Jayanta, Chaudhuri, Sarbajit
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Revisiting the Apparent Paradox: Foreign Capital Inflow, Welfare Amelioration and ‘Jobless Growth’ with Agricultural Dualism and Non-traded Intermediate Input [PDF]

open access: yes
In order to answer the pertinent question why developing countries are showing penchant for foreign capital over the last two decades in spite of its detrimental effects as revealed from the conventional two-sector mobile capital version of Harris–Todaro
Mukherjee, Soumyatanu
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Indeterminate Dualism against Repugnance [PDF]

open access: yes
An indeterminate version of Henry Sidgwick’s “Dualism of Practical Reason” may offer a solution to Derek Parfit’s “Repugnant Conclusion”. Here we will outline the problem of Sidgwick’s Dualism and how to resolve it within the framework of practical ...
Barta, Walter
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Emergent Dualism: Why and How? [PDF]

open access: yes, 2015
The main aim of this essay is to try to clarify a central question concerning the coherence of emergent dualism. The question is approximately this: How should we articulate and defend emergent dualism, if emergence is mostly interpreted as a kind of ...
Corradini, Antonella
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Mind and Consciousness

open access: yesSt Andrews Encyclopaedia of Theology
Mind and consciousness are philosophically and theologically significant in many religious and secular traditions. This article focuses on the importance of the concepts of mind and consciousness in Christian theological views of human nature and God ...
Charles Taliaferro
doaj  

Is dualism still a source of convergence in Europe? [PDF]

open access: yes
This paper aims at assessing whether dualistic mechanisms represent a significant component of the aggregate labour productivity convergence observed across the European regions in the 1980s. The potential of an explanation of convergence based - in part,
Francesco Pigliaru, Raffaele Paci
core  

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