Results 61 to 70 of about 35,338 (286)
, 2013 Kelsen defends (a) monism, that is, the view that international law and the various state legal systems taken together constitute a unified normative system, and (b) the primacy of international law over state law within the monistic framework. He argues
Spaak, Torben
core +1 more source
Jak powstaje świadomość ciała? (How does consciousness of the body arise?) [PDF]
Analiza i Egzystencja, 2010 First sections of the article present the historical background of the twentieth century philosophy of the human body. Then the author analyzes main elements of Husserlian theory of the constitution of the body: constitution of visual, tactual and ...
Stanisław Judycki
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Trans/Form/Ação, 2005 Baseado nas reflexões de Nietzsche sobre a ação humana e o além-do-homem, este artigo discute sua crítica demolidora à ética clássica à luz do contexto mais amplo do século XIX de desconstrução dos valores éticos enraizados até então.
Mariana Paolozzi Sérvulo da Cunha
doaj +1 more source
The Structure and Dynamics Argument against Materialism Revisited
Problemos, 2020 Alter (2016) elaborates and defends an ambitious argument advanced by Chalmers (2002) against physicalism. As Alter notes, the argument is valid. But I will argue that not all its premises are true. In particular, it is false that all physical truths are
Andrei Mărăşoiu
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Indeterminate Dualism against Repugnance [PDF]
An indeterminate version of Henry Sidgwick’s “Dualism of Practical Reason” may offer a solution to Derek Parfit’s “Repugnant Conclusion”. Here we will outline the problem of Sidgwick’s Dualism and how to resolve it within the framework of practical ...
Barta, Walter
core +3 more sources
Dualism and cross-country growth regressions [PDF]
This paper examines whether growth regressions should incorporate dualism and structural change. If there is a differential across sectors in the marginal product of labour, changes in the structure of employment can raise aggregate total factor ...
Ludger Woessmann, John Temple
core +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source