Results 61 to 70 of about 24,560 (302)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Substantively revised version of the Stanford Encyclopedia of Philosophy's entry on mind-body dualism.
Ralph Weir (17169727) +1 more
core
Descartes and the “metaphysical dualism”: Excesses in interpreting a classic [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2010 The article focuses on one of the most serious accusations brought against Descartes and modern philosophy, namely “the dualism of substance”. The accusers claim that the human body and soul were viewed as completely separate; consequently, their ...
Ştefan Afloroaei
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2007 This paper attempts to show the origin of dualism in JudeoChrisitian tradition. Close analysis of 1QS, so-called "Discipline of Community," which was discovered in 1948 in Qumran, reveals that Christian dualism found in New Testament has its precedents ...
배철현
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Rhetorical Dualism and the Orthodox/Heterdox Distinction in Economics [PDF]
This paper attempts to combine elements of the approaches of two influential economists, Sheila Dow and Deirdre McCloskey and expands on previous work (2005) on Dow’s concept of dualism.
Andrew Mearman
core
Petroleum Exploration and Development:: In the late 1970s, the theory of coal-formed gas began to take root, sprout, develop, and improve in China. After decades of development, a complete theoretical system was finally formed. The theory of coal-formed gas points out that coal measures are
Chengzao JIA +8 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source