Results 51 to 60 of about 150,119 (305)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Redukcje świadomości i problem trzeciej drogi (Reductions of consciousness and the problem of a third way) [PDF]
Analiza i Egzystencja, 2010 The leading idea of the article is defined by a quotation from Fichte concerning the opposition between idealism and “dogmatism”, or naturalism. That opposition is interpreted as a result of two alternative “reductions of consciousness”: according to the
Małgorzata Kowalska
doaj
The Role of Necessity in Facing the Problem of Evil in Plato's Philosophy [PDF]
پژوهشنامه فلسفه دین, 2018 Plato, when dealing with the problem of evil, more than anything, tries to keep the good and the ideas transcendent and uninvolved in evil. Therefore, apart from the fact that he recognizes humans as the cause of some evil, he talks of a concept called ...
Mohammad Firuzkuhy +1 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Elisabeth of Bohemia as a Naturalistic Dualist [PDF]
, 2018 Elisabeth was the first of Descartes' interlocutors to press concerns about mind-body union and interaction, and the only one to receive a detailed reply, unsatisfactory though she found it.
Janssen-Lauret, Frederique
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Fission, First Person Thought, and Subject-body Dualism [PDF]
, 2017 In “The Argument for Subject Body Dualism from Transtemporal Identity Defended” (PPR 2013), Martine Nida-Rümelin (NR) responded to my (PPR 2013) criticism of her (2010) argument for subject-body dualism.
Ludwig, Kirk
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Judicial Defence of Constitutionalism in the Assessment of South Africa's International Obligations
Potchefstroom Electronic Law Journal, 2019 The (sometimes fragile) balance between South Africa's constitutional obligations to protect and promote human rights in the international arena and the realities of political practice is the focus of this paper.
Francois Venter
doaj +1 more source