Results 31 to 40 of about 6,634 (261)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Holism, individualism, personalism: from Platonic dualism to the dispute over a source and status of human individuality (N. Elias, I. Berlin, R. Rorty) [PDF]
Analiza i Egzystencja, 2015 Individualism as a way of feeling and comprehension of reality has been a basic element of Western civilization for a long time. In 20th century individualism was criticized by personalism and similar currents.
Zbigniew Ambrożewicz
doaj
Lagged development and economic dualism
PSL Quarterly Review, 2014 The work explores the hypothesis that today’s lagging economies, such as Italy, are not completely lacking in firms that are capable of achieving high levels of productivity, rather they simply do not have enough of them to absorb a sizeable portion of ...
G. FUÀ
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The growth process in a "dual" economic system
PSL Quarterly Review, 2014 It may be said that the Italian economy has remained - after about three quarters of a century of industrial development along modern lines - roughly half “advanced” and half “primitive”.
V.C. LUTZ
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Redukcje świadomości i problem trzeciej drogi (Reductions of consciousness and the problem of a third way) [PDF]
Analiza i Egzystencja, 2010 The leading idea of the article is defined by a quotation from Fichte concerning the opposition between idealism and “dogmatism”, or naturalism. That opposition is interpreted as a result of two alternative “reductions of consciousness”: according to the
Małgorzata Kowalska
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