Results 101 to 110 of about 149,447 (303)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Basic Dualism in the World: Object-Oriented Ontology and Systems Theory
Open PhilosophyGraham Harman writes that the “basic dualism in the world lies…between things in their intimate reality and things as confronted by other things.” However, dualism implies irreconcilable difference; what Harman points to is better expressed as a dyad ...
Zwick Martin
doaj +1 more source
Volition and Property Dualism [PDF]
, 2003 My overall aim here is to intersect two issues central to Max Velmans’ (2002) wide-ranging paper. The first concerns one of the most vexing problems in consciousness research — how best to approach the terms ‘mental’ and ‘physical’.
Mangan, Dr. Bruce B.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Concerns with mutual constitution: a critical realist commentary [PDF]
, 2005 The case for “analytical dualism” as a means of approaching sociotechnical action is presented as an alternative to accounts which tend to conflate agency, structure, and technology.
Mutch, A
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Гуманитарные и юридические исследования, 2021 The article considers the role and place of Reichstag and meetings of Prince Electors during the Thirty Years’ War. The author underlines that Prince Electors’ meetings promoted the strengthening of their positions in state and political structure of the
Y. E. Ivonin
doaj
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
A Few Notes on Religious Dualism in the Works of Ramón López Velarde [PDF]
University of Bucharest Review. Literary and Cultural Studies Series, 2015 López Velarde (RLV) has long been regarded as Mexico’s ‘national poet’. Among other important themes, such as the idealization of the Mexican hinterland, his prose and verse are characterized by a very stark dualism: flesh and spirit, Catholic devotion ...
Luis Solis, Celene García
doaj