Results 131 to 140 of about 86,962 (305)
Muscular dystrophy in an X; 1 translocation female suggests that Duchenne locus is on X chromosome short arm. [PDF]
, 1979 R H Lindenbaum +4 more
openalex +1 more source
Combating muscle atrophy: emerging therapeutic targets that are fiber‐type‐specific
The FEBS Journal, EarlyView.Inflammation, denervation or decreased insulin signaling activate proteolysis and cause muscle wasting. Pathological conditions like obesity and DMD can also exacerbate atrophy via PGD2–RhoA–ROCK2 signaling. In contrast, exercise, dietary interventions, and pharmacological agents can activate Ca2+/calcineurin–NFAT and AMPK–PGC‐1α–MEF pathways ...
Samrat Chakraborty +2 more
wiley +1 more source
A possible role for electron microscopy in detection of carriers of Duchenne type muscular dystrophy [PDF]
, 1973 Adel K. Afifi +2 more
openalex +1 more source
Experimental Physiology, EarlyView.Abstract Duchenne muscular dystrophy (DMD) is characterized by respiratory muscle injury and weakness, ultimately leading to respiratory failure. Impaired respiratory muscle performance, fibrosis and inflammation in early disease are evident in the dystrophin‐deficient mdx mouse model of DMD.
Michael N. Maxwell +3 more
wiley +1 more source
A Double-blind Controlled Trial of Penicillamine Therapy in Duchenne Muscular Dystrophy — Interim Comments [Abstract] [PDF]
, 1977 Walter G. Bradley +2 more
openalex +1 more source
Weighted cart pull: A novel outcome measure for sustained motor function in mice
Experimental Physiology, EarlyView.Abstract Sarcopenia, the pathological age‐related decline in muscle mass and strength, compromises independence and quality of life in older adults. Currently, no effective treatments are available. To enhance translational research using aged mouse models, we developed and validated the weighted cart pull (WCP) as a novel assessment of sustained motor
Charles D. Brennan +12 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2017 David Feder,1 Miriam Eva Koch,1 Beniamino Palmieri,2 Fernando Luiz Affonso Fonseca,1 Alzira Alves de Siqueira Carvalho3 1Pharmacology Department, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil; 2Department of General Surgery ...
Feder D +4 more
doaj
The Journal of Physiology, EarlyView.Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina +7 more
wiley +1 more source
Quantitative electromyography: carrier detection in Duchenne type muscular dystrophy using a new automatic technique [PDF]
, 1972 A. Moosa, Brian Brown, Victor Dubowitz
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz +8 more
wiley +1 more source