Results 71 to 80 of about 86,962 (305)

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

Is cardiac autonomic modulation influenced by beta blockers in adolescents with Duchenne Muscular Dystrophy?

Translational Exercise Biomedicine
As the Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disorder frequently associated with cardiac dysfunction, this study aimed to evaluate the influence of beta-blocker therapy on cardiac autonomic modulation in adolescents with DMD by
Silva-Magalhães Talita Dias da, Moraes Íbis Ariana Peña de, Vanderlei Luiz Carlos Marques, Monteiro Carlos Bandeira de Mello, Silva Marcela Maria Carvalho da, Pereira Fernando, Dias Rodrigo Martins, Garner David, Grossklauss Luis Fernando, Dias de Carvalho Tatiana, Ferreira Celso   +10 more
doaj   +1 more source

Recent advances in echocardiography: strain and strain rate imaging [version 1; referees: 3 approved]

F1000Research, 2016
Deformation imaging by echocardiography is a well-established research tool which has been gaining interest from clinical cardiologists since the introduction of speckle tracking.
Oana Mirea, Jurgen Duchenne, Jens-Uwe Voigt   +2 more
doaj   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

CLINICAL CASE OF FAMILIAL DUCHENNE MYODYSTROPHY

Мать и дитя в Кузбассе, 2022
The article presents an analysis of a clinical case of the diagnosis of familial Duchenne myodystrophy in a newborn child confirmed in the neonatal period. The stages of diagnosis and their peculiarities are described.
Марина Афанасьевна Соколовская, Екатерина Сергеевна Макарцева, Елена Николаевна Гаврилова   +2 more
doaj  

Duchenne Muscular Dystrophy Newborn Screening: Evaluation of a New GSP^® Neonatal Creatine Kinase-MM Kit in a US and Danish Population

International Journal of Neonatal Screening, 2019
Duchenne muscular dystrophy (DMD/Duchenne) is a progressive X-linked disease and is the most common pediatric-onset form of muscular dystrophy, affecting approximately 1:5000 live male births. DNA testing for mutations in the dystrophin gene confirms the
Anne Timonen, Michele Lloyd-Puryear, David M. Hougaard, Liisa Meriö, Pauliina Mäkinen, Ville Laitala, Tuukka Pölönen, Kristin Skogstrand, Annie Kennedy, Sari Airenne, Hanna Polari, Teemu Korpimäki   +11 more
doaj   +1 more source

Facial Mimicry of Spontaneous and Deliberate Duchenne and Non-Duchenne Smiles [PDF]

Journal of Nonverbal Behavior, 2013
Increasing evidence suggests that Duchenne (D) smiles may not only occur as a sign of spontaneous enjoyment, but can also be deliberately posed. The aim of this paper was to investigate whether people mimic spontaneous and deliberate D and non-D smiles to a similar extent.
Krumhuber, EG, Likowski, KU, Weyers, P
openaire   +3 more sources

A Fast Path from Innovation to Safe and Effective Medicine

Clinical Pharmacology &Therapeutics, EarlyView.
Consistent progress in medicines development has allowed both for de novo treatment options and for the refinement of existing products that improve effectiveness or reduce harm. Nonetheless, unmet medical needs persist, particularly in rare diseases, pediatrics and underserved populations.
Peter Arlett, Falk Ehmann, Ralf Herold, Evdokia Korakianiti, Pierpaolo Moscariello, Liese Barbier, Iordanis Gravanis, Frank Pétavy, Emmanuel Cormier, Andrew Thomson, Spiros Vamvakas, Steffen Thirstrup   +11 more
wiley   +1 more source

Multiparametric Analysis of Nasal Inspiratory Pressure (SNIP) in Duchenne Muscular Dystrophy: A Case-Control Study With Healthy Subjects. [PDF]

Pediatr Pulmonol
ABSTRACT Background Individuals with Duchenne Muscular Dystrophy (DMD) exhibit respiratory muscle changes leading to fatigue and weakness, and assessing relaxation rates and contractile properties may help detect early fatigue. Aim To non‐invasively assess inspiratory muscle relaxation and contractile rates using sniff nasal inspiratory pressure (SNIP)
Santos IP, Marques L, da Fonseca JDM, Dourado ME, Otto-Yáñez M, Torres-Castro R, Pennati F, Aliverti A, Fregonezi GAF, Resqueti VR.   +9 more
europepmc   +2 more sources

Improving translational studies: lessons from rare neuromuscular diseases [PDF]

, 2015
Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
core   +3 more sources