Results 81 to 90 of about 42,113 (251)

Phenological turnover matters when making trait‐based predictions of plant–pollinator interactions

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Understanding the processes determining species' interactions is key to predicting and safeguarding ecological networks under rapid environmental change. One approach to estimating interactions is to use morphologies of taxa interacting across trophic levels to reveal ...
Aoife Cantwell‐Jones   +18 more
wiley   +1 more source

Transcriptional Diversity in Response to Aging Across Skeletal Muscles

open access: yesAging Cell, EarlyView.
We constructed transcriptional maps of 11 skeletal muscles from young and old mice, revealing age‐related tissue‐specific gene expression changes. Our findings highlight cellular composition shifts and new cell states in aged muscles, providing insights into muscle aging and potential therapeutic targets for age‐related muscle disorders. ABSTRACT Aging
Can Liu   +15 more
wiley   +1 more source

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

open access: yesCell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee   +13 more
wiley   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

open access: yesCell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang   +4 more
wiley   +1 more source

Parental perspectives on family‐centered care in pediatric neurology: An explanatory sequential mixed‐methods study

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
The proposed conceptual framework highlighting parents' central role in their child's healthcare experience. Abstract Aim To explore parents' experiences of family‐centered care (FCC) in a pediatric neurology clinic. Method In this explanatory sequential mixed‐methods study, parents of children with neurological conditions completed the Measure of ...
Ege Sarikaya   +21 more
wiley   +1 more source

Preimplantation genetic diagnosis associated to Duchenne muscular dystrophy

open access: yesEinstein (São Paulo)
Duchenne muscular dystrophy is the most common muscle disease found in male children. Currently, there is no effective therapy available for Duchenne muscular dystrophy patients. Therefore, it is essential to make a prenatal diagnosis and provide genetic
Bianca Bianco   +3 more
doaj   +1 more source

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