Results 71 to 80 of about 15,396 (178)

Family History of Chronic Pain: What Impact Does It Have on Current Clinical Status? Results From an Italian Study

open access: yesEuropean Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Although a key factor in understanding intergenerational transmission, family history of chronic pain deserves greater attention, particularly about its role as a potential mediating factor on current psychophysical status, together with other underestimated parameters (e.g., psychiatric comorbidity).
Simona Pupo   +5 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei   +9 more
wiley   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, Volume 81, Issue 8, Page 1057-1067, August 2026.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

Comparative clinical profile of mirtazapine and duloxetine in practical clinical settings in Japan: a 4-week open-label, parallel-group study of major depressive disorder

open access: yesNeuropsychiatric Disease and Treatment, 2013
Kei Nagao,1,2 Taro Kishi,1 Masatsugu Moriwaki,1 Kiyoshi Fujita,3,4 Shigeki Hirano,5 Yoshio Yamanouchi,1 Toshihiko Funahashi,2 Nakao Iwata1 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Department of ...
Nagao K   +7 more
doaj  

Association Between Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6482-6508, August 2026.
ABSTRACT Aims We aimed to examine the association between GLP‐1 RA use and suicidal ideation or behaviours through a systematic review of observational studies. Materials and Methods A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025. Observational studies investigating
Timothy H. Chan   +5 more
wiley   +1 more source

Risk of Psychiatric Worsening With GLP‐1 Receptor Agonist Use in Patients With Type 2 Diabetes and Treated Depression

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7048-7057, August 2026.
ABSTRACT Aims To compare 1‐year psychiatric outcomes after GLP‐1 receptor agonist (GLP‐1 RA) versus sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) initiation in patients with type 2 diabetes and treated depression. Materials and Methods We conducted a retrospective active‐comparator, new‐user cohort study using electronic health records from the ...
Yu Chang   +3 more
wiley   +1 more source

Pharmacological Influences on the R2 Blink Reflex Response in Healthy Participants: A Systematic Review

open access: yesEuropean Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Pharmacological modulation of the R2 blink reflex was comparable whether responses were elicited using standard patch or concentric electrodes. Across nine studies, noradrenergic and GABAergic interventions produced the most consistent effects, supporting the R2 blink reflex as a sensitive biomarker of trigeminofacial nociceptive processing.
Josh Murphy   +5 more
wiley   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation

open access: yesJournal of Clinical Periodontology, Volume 53, Issue 8, Page 1301-1311, August 2026.
ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long‐term effects on the risk of periodontitis remain unclear. Methods We emulated target trials using US electronic health records (1995–2019) to compare the 5‐year risk of incident ...
Ignacio Leiva‐Escobar   +7 more
wiley   +1 more source

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

open access: yesJournal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

The effect of duloxetine on stress urinary incontinence

open access: yesHealth Science Reports
Background and Aims This study aims to evaluate the effect of duloxetine on stress urinary incontinence (SUI) episode frequency (IEF) per week IEF. Methods In this clinical trial, 100 women aged 20−80 years with urinary incontinence were assessed based ...
Nahid Lorzadeh, Moghadaseh Jahanshahi
doaj   +1 more source

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