Structure of racemic duloxetine hydrochloride
Acta Crystallographica Section E: Crystallographic Communications, 2023 Duloxetine hydrochloride (trade name Cymbalta) is marketed as a single enantiomer (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propylaminium chloride, C18H20NOS+·Cl−, which is twice as effective as the (R)-enantiomer in serotonin uptake. Here, we
Mohan M. Bhadbhade +3 more
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Duloxetine hydrochloride loaded film forming dermal gel enriched with methylcobalamin and geranium oil attenuates paclitaxel-induced peripheral neuropathy in rats [PDF]
IBRO Reports, 2020 Objective: In attempt to conquer the major concerns of oral duloxetine hydrochloride (like low bioavailability, intolerable side-effects and no regeneration of demyelinated nerve fibres) for the management of chemotherapy-induced peripheral neuropathy ...
Jitender Madan, Rupinder Kaur Sodhi
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Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation [PDF]
Drug Delivery, 2017 Duloxetine hydrochloride (DH) is a serotonin–norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism.
Ahmed Hassen Elshafeey
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A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough [PDF]
BMC Pulmonary Medicine, 2023 Introduction Refractory cough, a chronic cough with an unclear diagnosis or poor treatment response. The symptoms are often stubborn and persistent, causing serious complications and lowering the patient's quality of life. Cough hypersensitivity syndrome
Shengyuan Wang +9 more
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Formulation study of duloxetine hydrochloride enteric-coated tablets
SN Applied Sciences, 2023 During storage, duloxetine hydrochloride may have an unexpected cross reaction with enteric coated acrylic resin, which may affect the product quality.
Jiang Guowei +4 more
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Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans [PDF]
Anais da Academia Brasileira de Ciências, 2022 This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced ...
RAQUEL T. MENEZES +4 more
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Simultaneous measurement of duloxetine hydrochloride and avanafil at dual-wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness [PDF]
BMC ChemistryThe simultaneous assay of duloxetine hydrochloride (DLX) and avanafil (AVN) in their pure forms, synthetic mixtures, and spiked human plasma was achieved using a novel, eco-friendly, sensitive, and specific HPTLC methodology that have been established ...
Sayed M. Derayea +3 more
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Preparation and evaluation of duloxetine hydrochloride enteric-coated pellets with different enteric polymers [PDF]
Asian Journal of Pharmaceutical Sciences, 2017 The main purpose of the present study was to prepare duloxetine hydrochloride (DXH) enteric-coated pellets using different enteric polymers. Three layers (drug-loaded layer, barrier layer, and enteric-coated layer) were applied to the inert core pellets,
Zhonggui He
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Anesth Essays Res, 2022 Background: Recently, opoids are linked with cancer recurrence. Duloxetine hydrochloride (DH), an anxiolytic may reduce total opoid requirement after cancer surgery.
Haider N +5 more
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International Journal of Electrochemical Science, 2012 A duloxetine ion selective membrane electrode is prepared. The electrode incorporates PVC membrane with duloxetine-silicomolybdate (DLX-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer.
Reda Ammar, Abdulrhman Al-Warthan
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