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Duloxetine Hydrochloride [PDF]

Definitions, 2020
T he hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT ) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake

semanticscholar   +2 more sources

QbD-Optimized RP-HPLC Method Development for Simultaneous Quantification of Pregabalin and Duloxetine Hydrochloride

Biophysica
Quality by design (QbD) is a systematic approach focused on achieving consistent, predictable quality based on predefined objectives. Unlike traditional methods, QbD prioritizes risk assessment and management, which significantly enhances the robustness ...
Indu Passi, Ram Kumar, Sushant Salwan, Pooja A. Chawla, Nisha Bansal, Bhupinder Kumar   +5 more
doaj   +2 more sources

Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine

Diabetes, Metabolic Syndrome and Obesity, 2010
Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent ...
Russell J, Zilliox L
doaj   +3 more sources

Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials [PDF]

BMC Neurology, 2008
Background Duloxetine hydrochloride is a reuptake inhibitor of 5-hydroxytryptamine and norepinephrine used to treat depression, generalized anxiety disorder, neuropathic pain, and stress incontinence in women.
Derry Sheena, Gaskell Helen, Sultan Asquad, Moore R Andrew   +3 more
doaj   +3 more sources

A green TLC–densitometric bioanalytical method for concurrent determination of duloxetine and risperidone in human plasma with in-silico DDI evaluation [PDF]

BMC Chemistry
Schizophrenia is a chronic, complex and severs psychiatric disorder that impacts men and women globally. The combined use of atypical antipsychotics; risperidone (RSP), and antidepressants medications; duloxetine hydrochloride (DLX), has grown more ...
Fatma Magdy, Raghda A. Emam, Basma H. Anwar   +2 more
doaj   +2 more sources

Advanced Analytical and Bioanalytical Estimation of Duloxetine Hydrochloride – An Overview

International Journal of Pharmaceutical Sciences Review and Research, 2020
Duloxetine HCl is a drug for the treatment of neuropathic pain associated with peripheral neuropathy especially diabetic polyneuropathy for which it is first line, and as an add-on treatment in stress urinary incontinence instead of surgery also ...
Kranthi Yalla, V. Vasudev
semanticscholar   +2 more sources

Therapeutic Potential of Nanocurcumin in Mitigating Duloxetine-Induced Hepatic Damage: Biochemical and Histopathological Insights. [PDF]

J Biochem Mol Toxicol
Nanocurcumin effectively protects against duloxetine‐induced liver injury in rats by enhancing antioxidant defenses and reducing inflammation. These findings support its potential as a therapeutic adjunct to mitigate hepatic side effects of duloxetine.
Abedi H, Jahromi MJ, Mohammadzade Z, Ebrahimi B, Abdollahzadeh P, Hassannezhad A, Sheikhnia F, Jahromi HK.   +7 more
europepmc   +2 more sources

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine. [PDF]

Pharmacol Res Perspect
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Maruoka J, Egami R, Akita Y, Kozuka K, Kakumoto Y, Kikuchi T, Kume K.   +6 more
europepmc   +2 more sources

Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
BACKGROUND Several studies have reported the association between osteoporosis and major depressive disorder (MDD) as well as the use of antidepressants.
Wei-Jun Zhou, Wen-Yun Zhou, Yonghao Bi, Zi-Yue Zhou, Zhi-Gao Zhou, Shaozhe Chen, Gang Xie, Zhen Lian, Guixin Yuan, Guanfeng Yao   +9 more
semanticscholar   +1 more source

Duloxetine Hydrochloride-Induced Oral Lichenoid Reaction: A Case Report. [PDF]

Med Princ Pract, 2015
<b><i>Objective:</i></b> To report the first case of duloxetine hydrochloride (DH)-induced oral lichenoid drug reaction (OLDR). <b><i>Clinical Presentation and Intervention:</i></b> A 57-year-old male patient presented with painful ulcerative lesions on the bilateral buccal mucosa of 2-year duration.
Kadam NS, Patil RA, Gurav AN, Shete A, Jadhav PD, Naik Tari R, Metkari S, Agarwal D.   +7 more
europepmc   +4 more sources